In response to RFA-EY-10-001, we are submitting a revised application for a National Eye Institute (NEI) Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Grant (T32) to develop a new training program in statistical genetics and genome informatics focused on eye diseases and vision disorders. The mission of this new training program will be to train pre-doctoral students and post-doctoral fellows to become research leaders adept in applying the tools of statistical genetics and bioinformatics to ocular diseases and vision disorders. This proposal brings together faculty with expertise in statistical genetics, genetic epidemiology, biostatistics, ophthalmology, molecular biology and bioinformatics from different departments in the Johns Hopkins University Bloomberg School of Public Health (SPH) and the School of Medicine (SOM). We will recruit pre-doctoral students from the Dept. of Epidemiology (primarily students in the Genetic Epidemiology Area of Concentration) and the Dept. of Biostatistics, as well as eligible post-doctoral fellows interested quantitative aspects of genomic research and will involve all trainees in ongoing research projects related to ocular genomics in the SOM (including the Wilmer Eye Institute and the Institute of Genetic Medicine). The 3 pre-doctoral and 1 post-doctoral trainees supported by this program will pursue a focused training program consisting of: didactic courses in statistical genetics, genetic epidemiology, biostatistics and genomic informatics. In addition t the Program Director and co-Program Director, 11 Core Faculty along with Affiliate Faculty in vision research and genetics and informatics will contribute to this program, representing the fields of statistical genetics, genetic epidemiology, computational statistics, biostatistics, molecular genetics, clinical genetics and ophthalmology. This revised application for new training program is designed to provide trainees with the multidisciplinary background essential to conduct quantitative studies in genomic research focused on ocular diseases and visual disorders.
This new training program will train pre-doctoral and post-doctoral fellows in epidemiology and biostatistics to conduct genomic research in ocular diseases and vision disorders by supporting their formal training at the Johns Hopkins Bloomberg School of Public Health. As part of their training, trainees will become actively involved in genomic research in vision disorders and eye diseases conducted at the Wilmer Eye Institute or the Institute of Genetic Medicine in the School of Medicine at Johns Hopkins.
|Powell-Wiley, Tiffany M; Ngwa, Julius; Kebede, Selomie et al. (2018) Impact of Body Mass Index on Heart Failure by Race/Ethnicity From the Get With The Guidelines-Heart Failure (GWTG-HF) Registry. JACC Heart Fail 6:233-242|
|Odeyemi, Yewande E; Lewis, O'Dene; Ngwa, Julius et al. (2018) Does Low FEV1 in Addition to Fixed Ratio and/or Lower Limit of Normal of FEV1/FVC Improve Prediction of Mortality in COPD? The NHANES-III-linked-mortality Cohort. J Natl Med Assoc :|
|Ngwa, Julius S; Fungwe, Thomas V; Ntekim, Oyonumo et al. (2018) Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Dement Geriatr Cogn Disord 45:66-78|
|Merino, Jordi; Dashti, Hassan S; Li, Sherly X et al. (2018) Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry :|
|Lewis, O'Dene; Ngwa, Julius; Kibreab, Angesom et al. (2017) Body Mass Index and Intensive Care Unit Outcomes in African American Patients. Ethn Dis 27:161-168|
|Mozaffarian, Dariush; Dashti, Hassan S; Wojczynski, Mary K et al. (2017) Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One 12:e0186456|
|Graff, Mariaelisa (see original citation for additional authors) (2017) Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 13:e1006528|
|Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977|
|Allard, Joanne S; Ntekim, Oyonumo; Johnson, Steven P et al. (2017) APOE?4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study. Exp Gerontol 87:129-136|
|Graff, Mariaelisa (see original citation for additional authors) (2017) Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 13:e1006972|
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