The Cole Eye Institute Vision Science Training Program (CEIVSTP) is specifically designed to train pre-doctoral Ph.D. students, medical students and post-doctoral fellows to become future leaders in ophthalmology research. One of the major long-term goals of CEIVSTP is to limit and eventually merge the boundaries that now separate clinical and basic research in ophthalmology. This training program is uniquely positioned to achieve this goal for the following reasons: First, the trainers in this program have been selected for their ability to perform outstanding ophthalmology research with a translational focus on eye diseases. Second, the clinical mentors in the program are highly successful clinicians with proven track records in research and a commitment to the goals of the training program. Third, both a basic and clinician scientist will mentor each trainee. Fourth, the housing of this program under one roof in the Cole Eye Institute establishes a cohesive and comprehensive environment particularly suited to this purpose. Fifth, the close interactions between medical students and Ph.D. students during the research training, will promote communication between the clinical and basic areas and foster scientific networks and collaborations that can continue into the future. The strong didactic, research and clinical component of this program together with the novel curriculum of the Molecular Medicine Ph.D. program will provide a solid foundation in basic scientific principles in the context of human ocular biology and disease. This proposal seeks funding for outstanding pre-doctoral graduate students, medical students working toward a masters level thesis and post-doctoral fellows committed to ophthalmic research.

Public Health Relevance

A major goal of the Cole Eye Institute Vision Science Training Program is to train the future leaders in vision science research and to bridge the gap between basic science ophthalmic research and clinical ophthalmology.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
1T32EY024236-01A1
Application #
8855069
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Agarwal, Neeraj
Project Start
2015-04-01
Project End
2020-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Gragg, Megan; Park, Paul S-H (2018) Misfolded rhodopsin mutants display variable aggregation properties. Biochim Biophys Acta Mol Basis Dis 1864:2938-2948
Runkle, Anne P; Srivastava, Sunil K; Yuan, Alex et al. (2018) FACTORS ASSOCIATED WITH DEVELOPMENT OF DISSOCIATED OPTIC NERVE FIBER LAYER APPEARANCE IN THE PIONEER INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY STUDY. Retina 38 Suppl 1:S103-S109
Pollock, Lana M; Xie, Jing; Bell, Brent A et al. (2018) Retinoic acid signaling is essential for maintenance of the blood-retinal barrier. FASEB J 32:5674-5684
Runkle, Anne P; Kaiser, Peter K; Srivastava, Sunil K et al. (2017) OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study. Invest Ophthalmol Vis Sci 58:3683-3689
Whitson, Jeremy A; Wilmarth, Phillip A; Klimek, John et al. (2017) Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins. Free Radic Biol Med 113:84-96
Whitson, Jeremy A; Zhang, Xiang; Medvedovic, Mario et al. (2017) Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis. Invest Ophthalmol Vis Sci 58:2666-2684
Mishra, Ashish K; Gragg, Megan; Stoneman, Michael R et al. (2016) Quaternary structures of opsin in live cells revealed by FRET spectrometry. Biochem J 473:3819-3836
Gragg, Megan; Kim, Tae Gyun; Howell, Scott et al. (2016) Wild-type opsin does not aggregate with a misfolded opsin mutant. Biochim Biophys Acta 1858:1850-9
Ataca, Dalya; Caikovski, Marian; Piersigilli, Alessandra et al. (2016) Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. Biol Open 5:1585-1594
Dubail, Johanne; Vasudevan, Deepika; Wang, Lauren W et al. (2016) Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep 6:33974

Showing the most recent 10 out of 11 publications