This multi-disciplinary Medical Scientist Training Program (MSTP) is designed to integrate training in clinical medicine and biomedical science for M.D./Ph.D. trainees. The goal is to train physician-scientists who, because of rigorous education in these two complementary areas, are well-equipped biomedical investigators. The University of California, San Diego (UCSD) campus has considerable strength in the biomedical sciences, which is enhanced by the local community and nearby scientific institutions in La Jolla, California. The strong ties between the School of Medicine (SOM), the Skaggs School of Pharmacy and Pharmaceutical Science (SSPPS), the adjoining UCSD General Campus, Jacobs School of Engineering, nearby research institutes (e.g., the Salk Institute for Biological Studies, the Scripps Research Institute [TSRI], the Sanford Consortium for Regenerative Medicine, the Sanford Burnham Prebys Medical Discovery Institute, the La Jolla Institute for Allergy and Immunology) and the San Diego biomedical community, create an academic environment highly suited for this MSTP and for the interdigitation of basic science, biomedical research and medical practice. This integrative education starts with research efforts and a Bioinformatics Boot Camp before SOM coursework begins and continues with research efforts in the summer between the first two years of the preclinical SOM Integrated Scientific Curriculum. Students explore research opportunities and fulfill academic requirements in Graduate Programs during medical school elective time and choose a Graduate Program near the end of their preclinical curriculum. The Graduate Training Programs that a trainee chooses is dependent on the research area of the Ph.D. thesis advisor and include but are not limited to Biomedical Sciences, Bioengineering, Neuroscience, Biological Sciences and the TSRI Program in Chemical and Biological Sciences. A required clinical clerkship prior to graduate studies provides the trainees a clinical experience, which facilitates medical education during research and along with a clinical re-immersion course we created, helps prepare them for the transition back from Ph.D. training to clinical clerkships in the SOM for completion of the M.D. degree. We seek to individualize each trainee's educational program. The MSTP engages in numerous activities to enhance this combined degree training program and build a sense of community among trainees embarking on careers as physician scientists. During the current funding period, the UCSD-MSTP has introduced a number of changes that we believe have enhanced the Program. This MSTP is successful, as shown by the numerous graduates who enter academic medicine and have careers as physician-scientists.

Public Health Relevance

This application seeks to continue long-standing support for the UCSD Medical Scientist (M.D./Ph.D.) Training Program (MSTP), which combines both M.D. (through an Integrated Scientific Curriculum in the UCSD School of Medicine) and Ph.D. training in areas of the biomedical sciences, including cellular and molecular biology, neuroscience, and bioengineering. Excellent trainees are recruited throughout the United States and graduates typically pursue careers as academic physician scientists. This MSTP has evolved through not only expanding research opportunities and support at UCSD and affiliated institutions (Salk Institute for Biological Sciences and the Scripps Research Institute) but also growing a pool of diverse, high quality applicants and faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007198-46
Application #
9793139
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Maas, Stefan
Project Start
1975-07-01
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
46
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Shah, Sahil H; Goldberg, Jeffrey L (2018) The Role of Axon Transport in Neuroprotection and Regeneration. Dev Neurobiol 78:998-1010
Wang, Lawrence T; Bwambale, Robert; Keeler, Corinna et al. (2018) Private sector drug shops frequently dispense parenteral anti-malarials in a rural region of Western Uganda. Malar J 17:305
Mesci, Pinar; Macia, Angela; Moore, Spencer M et al. (2018) Blocking Zika virus vertical transmission. Sci Rep 8:1218
Groves, Aran; Kihara, Yasuyuki; Jonnalagadda, Deepa et al. (2018) A Functionally Defined In Vivo Astrocyte Population Identified by c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate-Early Astrocytes (ieAstrocytes). eNeuro 5:
King, Liam B; Fusco, Marnie L; Flyak, Andrew I et al. (2018) The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe 23:101-109.e4
Feneis, Jennifer F; Kyubwa, Espoir; Atianzar, Kimberly et al. (2018) 4D flow MRI quantification of mitral and tricuspid regurgitation: Reproducibility and consistency relative to conventional MRI. J Magn Reson Imaging 48:1147-1158
Martins, Vitor F; Tahvilian, Shahriar; Kang, Ji H et al. (2018) Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55? Subunit of Phosphoinositide 3-Kinase. Front Physiol 9:789
Hsu, Cynthia L; Lee, Elian X; Gordon, Kara L et al. (2018) MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun 9:942
Cowell, Annie N; Istvan, Eva S; Lukens, Amanda K et al. (2018) Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science 359:191-199
Shi, Guoli; Ozog, Stosh; Torbett, Bruce E et al. (2018) mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Proc Natl Acad Sci U S A 115:E10069-E10078

Showing the most recent 10 out of 306 publications