This is a renewal application to support the Medical Scientist Training Program (MSTP) at Washington University in St. Louis. The overarching goal of the MSTP is to provide in-depth pre-doctoral training in clinical medicine and biomedical research for individuals desiring careers as physician-scientists. The applicant pool is strong and in the past funding period, the MSTP made significant strides in recruiting diversity students. Medical training is provided by the School of Medicine and research training is carried out in the interdisciplinary graduate programs of the Division of Biology and Biomedical Sciences, and in the Departments of Biomedical Engineering and Anthropology. Together, these graduate programs encompass nearly all contemporary areas of biomedical research. The basic components of the MSTP are: 1) Two years of the preclinical medical school curriculum; 2) Coursework in a biomedically relevant discipline; 3) Three or more years of original, hypothesis-driven research leading to completion of a doctoral thesis; 4) At least 15 months of clinical training; and 5) A wealth of academic and social programs designed to enhance the program and cohesiveness of the student body. The M.D. and Ph.D. degrees are awarded jointly at the successful completion of both components which typically takes 7-8 years, a period shortened by integrating both curricula. Upon completion of subsequent postgraduate training, MSTP alumni will be prepared to enter the workforce as physician-scientists. Based on the track record of this program, the vast majority will join the faculty of te nation's medical schools while others will contribute to the nation's biomedical research enterprise in government laboratories, biotechnology firms, and the pharmaceutical industry. Regardless of their position, their MSTP training will allow them to bridge the gap between the basic laboratory and the clinic. The success of this program is due to strong institutional support and continued funding of this grant. Thus, this renewal application seeks continued support for 55 students annually for 36 months each with the goal of graduating 20-25 MSTP students each year over the period of this grant.

Public Health Relevance

The Medical Scientist Training Program at Washington University is a pre-doctoral program that trains future physician-scientists for careers where they will have the abilities to treat patients, teach medical students and scientists, and conduct cutting-edge research that improves human health and eradicates disease. They will be uniquely qualified to help bridge the gap between the research laboratory and the clinic.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM007200-42S2
Application #
9304379
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Preusch, Peter
Project Start
1975-07-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
42
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Ligon, Marianne M; Mysorekar, Indira U (2018) Trans-mission control in the urinary tract: Local cytokine regulation of monocyte proliferation to combat infection. J Leukoc Biol 103:5-7
Barnette, Dustyn A; Davis, Mary A; Dang, Na L et al. (2018) Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochem Pharmacol 156:10-21
Klein, Roger D; Shu, Qin; Cusumano, Zachary T et al. (2018) Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation. MBio 9:
Lin, Joseph B; Sene, Abdoulaye; Wiley, Luke A et al. (2018) WNT7A/B promote choroidal neovascularization. Exp Eye Res 174:107-112
Wang, Zhuo A; Li, Lucy X; Doering, Tamara L (2018) Unraveling synthesis of the cryptococcal cell wall and capsule. Glycobiology 28:719-730
Li, Lucy X; Rautengarten, Carsten; Heazlewood, Joshua L et al. (2018) UDP-Glucuronic Acid Transport Is Required for Virulence of Cryptococcus neoformans. MBio 9:
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. J Lipid Res 59:1414-1423
Stopschinski, Barbara E; Holmes, Brandon B; Miller, Gregory M et al. (2018) Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus ?-synuclein and ?-amyloid aggregates. J Biol Chem 293:10826-10840
Verbaro, Daniel J; Sakurai, Nagisa; Kim, Byungil et al. (2018) Cutting Edge: The Histone Methyltransferase G9a Is Required for Silencing of Helper T Lineage-Associated Genes in Proliferating CD8 T Cells. J Immunol 200:3891-3896
Grither, Whitney R; Longmore, Gregory D (2018) Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A 115:E7786-E7794

Showing the most recent 10 out of 387 publications