The Stony Brook University Genetics Program is a graduate educational and research program leading to the Ph.D. degree in Genetics. The Genetics Program provides a unique, multi-institutional curriculum of course and laboratory research that draws upon the diverse faculty and resources of Stony Brook University (SBU), Cold Spring Harbor Lab (CSHL) and Brookhaven National Laboratory (BNL). These three research pillars of our Graduate Program provide a rich and didactic training experience for a small, highly select class of graduate students who enroll in the Graduate School of SBU, but who receive research and educational training from the three participating institutions. The Program was initiated in 1980, and it has been continuously funded by this NIH training grant since 1981. The Genetics Program faculty members have active, funded research labs affiliated with multiple departments of the participating Institutions. Program participants include four faculty members from BNL, 29 from CSHL and 57 from SBU. All share a deep interest in genetics and manage active research programs encompassing some aspect of modern genetics. This wide and varied mix of faculty and research expertise affords the graduate students with many opportunities for scientific interaction, collaboration and instruction. Students take core coursework in their first year, alongside research rotation experiences from which they choose a thesis research lab. Students also complete two semesters of an undergraduate teaching assistantship. After completing coursework, students complete a qualifying exam followed by a thesis research proposal defense. Students learn to analyze and present their own scientific findings, and those of others, through a student seminar series, first and second year student symposia, an annual retreat and numerous Journal clubs. An annual thesis research committee meeting and a final thesis research dissertation defense constitute the balance of the training program. With this proposal we seek to extend our commitment to maintaining this world-class Graduate Training Program.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Haynes, Susan R
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State University New York Stony Brook
Schools of Arts and Sciences
Stony Brook
United States
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Torres, AnnMarie; Luke, Joanna D; Kullas, Amy L et al. (2016) Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming. J Leukoc Biol 99:387-98
Vink, Elizabeth I; Zheng, Yueting; Yeasmin, Rukhsana et al. (2015) Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression. Viruses 7:2428-49
Nakayama, Takuya; Fish, Margaret B; Fisher, Marilyn et al. (2013) Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. Genesis 51:835-43
Lachance, Joseph; Jung, Lawrence; True, John R (2013) Genetic background and GxE interactions modulate the penetrance of a naturally occurring wing mutation in Drosophila melanogaster. G3 (Bethesda) 3:1893-901
Kullas, Amy L; McClelland, Michael; Yang, Hee-Jeong et al. (2012) L-asparaginase II produced by Salmonella typhimurium inhibits T cell responses and mediates virulence. Cell Host Microbe 12:791-8
Lachance, Joseph; Johnson, Norman A; True, John R (2011) The population genetics of X-autosome synthetic lethals and steriles. Genetics 189:1011-27
Lachance, Joseph; True, John R (2010) X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species. Evolution 64:3035-46
Lachance, Joseph (2010) Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations. BMC Med Genomics 3:57
Lachance, Joseph (2009) Inbreeding, pedigree size, and the most recent common ancestor of humanity. J Theor Biol 261:238-47
Lachance, Joseph (2009) Detecting selection-induced departures from Hardy-Weinberg proportions. Genet Sel Evol 41:15

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