This application requests continuing Medical Scientist Training Program (MSTP) support for the Combined MD/PhD Training Program at the University of Minnesota. The Program remains committed to a single common goal: to train the next generation of physician scientist-leaders equipped to push technology and clinical application to a level of investigative excellence consonant with the best biomedical research in the world. ? ? The MSTP is designed to provide instruction leading to the MD and PhD degrees in 7-8 years. The Program employs the traditional training sequence of medical school (2 years) > graduate school (3-5 years) > medical school (1.5-2 years). However, exciting new curricular changes are facilitating the transition between the two degree components. The centerpiece is a new course entitled """"""""Ambulatory Clinics for the Physician Scientist"""""""". This course allows students to work side-by-side with the physician scientist of their choosing, thereby exposing students in the latter phases of graduate training to the joy of interfacing their basic science skills to specific clinical problems. Research opportunities abound in the laboratories of the 121 faculty preceptors. Areas of excellence include Biochemistry, Biomedical Engineering, Cancer Biology, Cell Biology, Chemistry, Developmental Biology, Epidemiology, Genetics, Immunology, Microbiology, Neuroscience and Pharmacology. ? ? The research opportunities are supported by a major expansion of laboratory facilities during the last several years, resulting in an infrastructure of instrumentation and laboratory space that has enhanced research across the entire medical school. ? ? Students in the University of Minnesota MSTP can explore a comprehensive number of scientific challenges in contemporary biomedical research, coupled with a choice from all the major medical subspecialties for their clinical focus. Our graduates have in the past and are currently using their MSTP education as a springboard to conduct biomedical research in major medical schools across the United States, thereby fulfilling the national mission of this critical program in medical research and health care. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008244-19
Application #
7067114
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Shapiro, Bert I
Project Start
1988-07-01
Project End
2010-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
19
Fiscal Year
2006
Total Cost
$357,862
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Pathology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Sweis, Brian M; Redish, A David; Thomas, Mark J (2018) Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict. Nat Commun 9:2521
Angelos, Mathew G; Abrahante, Juan E; Blum, Robert H et al. (2018) Single Cell Resolution of Human Hematoendothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium. Stem Cells 36:206-217
Ebrahimi, Diako; Richards, Christopher M; Carpenter, Michael A et al. (2018) Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease. Nat Commun 9:4137
Titcombe, Philip J; Wigerblad, Gustaf; Sippl, Natalie et al. (2018) Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis. Arthritis Rheumatol 70:1933-1945
Lake, Eric W; Muretta, Joseph M; Thompson, Andrew R et al. (2018) Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states. Proc Natl Acad Sci U S A 115:E11894-E11903
Zick, Jennifer L; Blackman, Rachael K; Crowe, David A et al. (2018) Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia. Neuron 98:1243-1255.e5
Verma, Mayank; Asakura, Yoko; Murakonda, Bhavani Sai Rohit et al. (2018) Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling. Cell Stem Cell 23:530-543.e9
Sweis, Brian M; Abram, Samantha V; Schmidt, Brandy J et al. (2018) Sensitivity to ""sunk costs"" in mice, rats, and humans. Science 361:178-181
Csizmar, Clifford M; Petersburg, Jacob R; Hendricks, Alex et al. (2018) Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors. Bioconjug Chem 29:1291-1301
Breed, Elise R; Lee, S Thera; Hogquist, Kristin A (2018) Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection. Semin Cell Dev Biol 84:2-10

Showing the most recent 10 out of 108 publications