This application seeks renewal of the highly-successful Biophysics Training Grant Program at Columbia University. Training for the students in the Program is performed in the Departments of Biochemistry and Molecular Biophysics and Microbiology on the Health Sciences campus and the Departments of Biological Sciences and Chemistry on the Morningside campus. The Program provides a rich and diverse environment in which students apply a host of biophysical approaches to the investigation of important biological problems. The Program emphasizes the application of state-of-the-art biophysical techniques to provide trenchant answers to detailed, specific questions while at the same time it endeavors to expose the trainees to a vast array of biological processes and to fertile areas of future research. Forming the underpinnings of the Training Program are exceptional laboratories housed in four departments and outstanding facilities located on the two campuses, weekly seminars in biophysics given by outstanding visiting speakers, an annual biophysics retreat where trainees present their research to all of the students and faculty in the Program, and a core, year-long biophysics course. Over the past 5 years since the last competitive renewal, the Biophysics Training Program has made important strides in several critical areas: (i) the number of underrepresented minority students in the Program has been dramatically increased from one to five, (ii) several new trainers have been brought into the Program and the Program now has participation from two additional departments (Biological Sciences and Microbiology), and (iii) new procedures have been instituted for the appointment of trainees so as to assure that the most qualified students are selected for support. In the coming five year period, the Program will (i) reinforce ties between participating laboratories, departments and campuses, (ii) continue to improve the recruitment of all students, with an emphasis on underrepresented minority students, (iii) recruit additional talented faculty, and (iv) strengthen and update the pedagogical component of the program. The past historical successes and anticipated future achievements in the next funding period of the Biophysics Training Grant Program at Columbia will maintain this Program as a flagship for education and training of graduate students in New York City.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008281-17
Application #
6764082
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
17
Fiscal Year
2004
Total Cost
$317,420
Indirect Cost
Name
Columbia University (N.Y.)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Subramanyam, Shyamal; Kinz-Thompson, Colin D; Gonzalez Jr, Ruben L et al. (2018) Observation and Analysis of RAD51 Nucleation Dynamics at Single-Monomer Resolution. Methods Enzymol 600:201-232
Hsu, Andrew; O'Brien, Paul A; Bhattacharya, Shibani et al. (2018) Enhanced spectral density mapping through combined multiple-field deuterium 13CH2D methyl spin relaxation NMR spectroscopy. Methods 138-139:76-84
Hsu, Andrew; Ferrage, Fabien; Palmer 3rd, Arthur G (2018) Analysis of NMR Spin-Relaxation Data Using an Inverse Gaussian Distribution Function. Biophys J 115:2301-2309
Gaschler, Michael M; Andia, Alexander A; Liu, Hengrui et al. (2018) FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol 14:507-515
Gaschler, Michael M; Hu, Fanghao; Feng, Huizhong et al. (2018) Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis. ACS Chem Biol 13:1013-1020
Dionne, Gilman; Qiu, Xufeng; Rapp, Micah et al. (2018) Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture. Neuron 99:480-492.e5
Kinz-Thompson, Colin D; Gonzalez Jr, Ruben L (2018) Increasing the Time Resolution of Single-Molecule Experiments with Bayesian Inference. Biophys J 114:289-300
O'Brien, Paul A; Palmer 3rd, Arthur G (2018) TROSY pulse sequence for simultaneous measurement of the 15N R1 and {1H}-15N NOE in deuterated proteins. J Biomol NMR 70:205-209
Singh, Appu K; Saotome, Kei; Sobolevsky, Alexander I (2017) Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep 7:10669
Rogawski, Rivkah; Sergeyev, Ivan V; Zhang, Yinglu et al. (2017) NMR Signal Quenching from Bound Biradical Affinity Reagents in DNP Samples. J Phys Chem B 121:10770-10781

Showing the most recent 10 out of 83 publications