Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008601-02
Application #
2872596
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Adams, Claire A; Melikishvili, Manana; Rodgers, David W et al. (2009) Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA. J Mol Biol 389:248-63
Rasimas, Joseph J; Dalessio, Paula A; Ropson, Ira J et al. (2004) Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase. Protein Sci 13:301-5
Rasimas, Joseph J; Pegg, Anthony E; Fried, Michael G (2003) DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. J Biol Chem 278:7973-80
Rasimas, Joseph J; Kanugula, Sreenivas; Dalessio, Paula M et al. (2003) Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. Biochemistry 42:980-90