We seek renewal of the """"""""Research Training in Pharmaceutical Sciences"""""""" (RTPS Predoctoral Training Grant). RTPS is designed for students who want to extend their knowledge of molecular and cell biology to include principles of modern pharmacology and molecular imaging, and the application of these disciplines at cellular and organismal levels. RTPS adds formal instruction in chemical, cellular and organismal pharmacology and in molecular imaging, and emphasizes their applications in both cellular and whole animal contexts. RTPS faculty have expertise in cell/molecular biology, biochemistry, pharmacology, genomics and molecular imaging. Development of microPET imaging procedures and PET reporter gene technologies now permit application of molecular and cellular pharmacology to living animals, whose genomes can be experimentally manipulated, to complement existing molecular and light microscopic techniques. RTPS provides vertical integration of research in molecular and cellular pharmacology from molecule to mouse to man, combining concepts and applications from molecular structure through molecular medicine. Proposed training faculty increase from 24 in the current period to 36 in this application, include 10 Professors, 12 Associate Professors and 14 Assistant Professors, and come from seven departments. A majority, 22, of the mentors have primary or joint appointments in the Department of Molecular and Medical Pharmacology (DMMP). DMMP dominance results from two factors: (1) DMMP emphasis on modern pharmacologic and imaging techniques and the interface of cell biology, pharmacology and molecular imaging in DMMP and (2) recruitment of 10 new faculty, with research interests at the heart of the RTPS program, into DMMP in the last five years. The large number of junior faculty mentors reflects an institutional commitment to recruitment of faculty with research interests that reflect RTPS goals. Students are selected for RTPS after their first year in graduate school, and are drawn from a pool that comes from individual degree granting programs, the UCLA ACCESS graduate admissions program, the MSTP program and the UCLA STAR program. RTPS began in 1998, with the appointment of two students. Because of an increase in interest in this area of research, both by faculty and by students, we are requesting four trainee slots per year. Resources of the DMMP and the Crump Institute for Molecular Imaging will be available to all RTPS students, regardless of the department in which they receive their Ph.D.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008652-06
Application #
6604979
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
1998-07-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
6
Fiscal Year
2003
Total Cost
$209,933
Indirect Cost
Name
University of California Los Angeles
Department
Pharmacology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Tekeste, Shewit S; Wilkinson, Thomas A; Weiner, Ethan M et al. (2015) Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication. J Virol 89:12058-69
Plaisier, Seema B; Taschereau, Richard; Wong, Justin A et al. (2010) Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures. Nucleic Acids Res 38:e169
Briones, Marisa S; Dobard, Charles W; Chow, Samson A (2010) Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core. J Virol 84:5181-90
Sirk, Shannon J; Olafsen, Tove; Barat, Bhaswati et al. (2008) Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2. Bioconjug Chem 19:2527-34
Burton, Jeremy B; Johnson, Mai; Sato, Makoto et al. (2008) Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nat Med 14:882-8
Venisnik, Katy M; Olafsen, Tove; Gambhir, Sanjiv S et al. (2007) Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging. Mol Imaging Biol 9:267-77
Brakenhielm, Ebba; Burton, Jeremy B; Johnson, Mai et al. (2007) Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int J Cancer 121:2153-61
Venisnik, Katy M; Olafsen, Tove; Loening, Andreas M et al. (2006) Bifunctional antibody-Renilla luciferase fusion protein for in vivo optical detection of tumors. Protein Eng Des Sel 19:453-60
Johnson, Mai; Huyn, Steve; Burton, Jeremy et al. (2006) Differential biodistribution of adenoviral vector in vivo as monitored by bioluminescence imaging and quantitative polymerase chain reaction. Hum Gene Ther 17:1262-9
Bjorndahl, Meit A; Cao, Renhai; Burton, Jeremy B et al. (2005) Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res 65:9261-8

Showing the most recent 10 out of 12 publications