In the Leadership in Pharmaceutical Biotechnology training program, students are provided a broad-based education that cuts across traditional departmental and field-of-study boundaries, blending disciplines of pharmaceutical science, chemical engineering, biochemistry and chemistry. This program operates in close collaboration industry at both the local and national levels, and is currently supported by a broad-based group of corporate sponsors that leverage NIH support to provide interdisciplinary education in pharmaceutical biotechnology to graduate students in the University of Colorado's Departments of Chemical and Biological Engineering, Pharmaceutical Sciences, and Chemistry and Biochemistry. The Leadership in Pharmaceutical Biotechnology training program has seven major thrusts: 1. Lecture and laboratory coursework designed to provide a broad-based education in pharmaceutical biotechnology 2. Laboratory rotations 3. An industrial mentor program designed to enhance both recruitment and retention of students 4. A summer internship program with our industrial collaborators 5. Interdisciplinary thesis research 6. Leadership activities, including training in research ethics 7. Seminars and symposia. These seven thrusts enable students to be educated in practical issues in pharmaceutical biotechnology (e.g., intellectual property issues, regulatory affairs and basic business concepts) as well as multidisciplinary scientific ones. This prepares students to perform well when they take subsequent positions in industry, academia, or government. To make sure that our research is rooted in practical problems, we rely heavily on our industrial colleagues as a source of new challenges that we may attempt to address. Students benefit from experiential training in non-academic settings, gaining an appreciation of the ever-changing biomedical and pharmaceutical industries. We incorporate active participation of our industrial mentors, industrial internships, and industrial seminar speakers to achieve this non-academic training.

Public Health Relevance

The Leadership in Pharmaceutical Biotechnology training Program provides graduate students with the interdisciplinary research training needed to produce industry and academic leaders. These leaders have the broad-based biotechnology knowledge needed to translate advances in biosciences and bioengineering into new therapeutic products for the benefit of human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008732-13
Application #
8496803
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gerratana, Barbara
Project Start
2001-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$216,969
Indirect Cost
$12,735
Name
University of Colorado at Boulder
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309
Carter, Kyle P; Carpenter, Margaret C; Fiedler, Brett et al. (2017) Critical Comparison of FRET-Sensor Functionality in the Cytosol and Endoplasmic Reticulum and Implications for Quantification of Ions. Anal Chem 89:9601-9608
Fiedler, Brett L; Van Buskirk, Steven; Carter, Kyle P et al. (2017) Droplet Microfluidic Flow Cytometer For Sorting On Transient Cellular Responses Of Genetically-Encoded Sensors. Anal Chem 89:711-719
Li, Jing; Yakushi, Tanya; Parlati, Francesco et al. (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol 13:486-493
Lauinger, Linda; Li, Jing; Shostak, Anton et al. (2017) Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol 13:709-714
Young, Alexandra M; Minson, Michael; McQuate, Sarah E et al. (2017) Optimized Fluorescence Complementation Platform for Visualizing Salmonella Effector Proteins Reveals Distinctly Different Intracellular Niches in Different Cell Types. ACS Infect Dis 3:575-584
Erickson, Keesha E; Otoupal, Peter B; Chatterjee, Anushree (2017) Transcriptome-Level Signatures in Gene Expression and Gene Expression Variability during Bacterial Adaptive Evolution. mSphere 2:
Otoupal, Peter B; Erickson, Keesha E; Escalas-Bordoy, Antoni et al. (2017) CRISPR Perturbation of Gene Expression Alters Bacterial Fitness under Stress and Reveals Underlying Epistatic Constraints. ACS Synth Biol 6:94-107
Chisholm, Carly Fleagle; Nguyen, Bao Han; Soucie, Kaitlin R et al. (2015) In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations. J Pharm Sci 104:3681-90
Smyth, Tyson; Kullberg, Max; Malik, Noeen et al. (2015) Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release 199:145-55
Bis, Regina L; Singh, Surinder M; Cabello-Villegas, Javier et al. (2015) Role of benzyl alcohol in the unfolding and aggregation of interferon ?-2a. J Pharm Sci 104:407-15

Showing the most recent 10 out of 56 publications