This proposal requests funds to support predoctoral trainees in a recently established and novel training program at Wake Forest University School of Medicine, which confers a doctorate in Molecular Medicine. The Molecular Medicine program addresses the critical need for generating talented research scientists who can pursue a career that lies at the interface between basic and clinical investigative medicine. There are several distinctive features of this Molecular Medicine graduate program. A team containing both an M.D. and a Ph.D. provides formalized mentoring for each trainee. Trainees become members of a newly established ? multidisciplinary NIH funded Program for Clinical Research (PCR), which provides administrative support for the Molecular Medicine Ph.D. program, a Masters in Molecular Medicine program for physicians, a Masters program in Epidemiology and Health Services for physicians and other health care professionals, and the MD/PhD program of the medical school. Complementary collegial and educational interactions occur among all trainees in the graduate programs. An emphasis is placed on training in the conduct of research/ethics, recruitment of minorities, career development in academic research, and marketing the program. Other novel features specific of the Molecular Medicine predoctoral program include a course involving direct interaction of trainees with physicians and patients, and a highly specialized didactic course to Molecular Basis of Human Disease. Trainees perform cutting-edge research that is focused in either human genetics and gene expression, or human cell biology (signaling, protein trafficking, growth and differentiation, and apoptosis). These research ? experiences translate to the fields of cancer, infectious and allergic diseases, cardiovascular diseases, diabetes, renal diseases, pain control, and the neuroscience of substance abuse. A multidisciplinary faculty comes from the clinical sciences Departments of Internal Medicine, Pediatrics, Surgery, and Anesthesiology, the basic sciences Departments of Biochemistry, Physiology and Pharmacology, Microbiology and Immunology, Cancer Biology, and Pathology, and from the newly established Center for Human Genetics. This training grant will allow continued growth and recruitment of the most competitive applicants and minorities into the Program. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM063485-02
Application #
6911746
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$168,999
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Pediatrics
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Akins, Elizabeth J; Moore, Miranda L; Tang, Shuai et al. (2010) In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice. Cancer Res 70:3473-82
Lewis, Eric M; Sergeant, Susan; Ledford, Bill et al. (2010) Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. J Biol Chem 285:2959-67
Akins, Elizabeth J; Dubey, Purnima (2008) Noninvasive imaging of cell-mediated therapy for treatment of cancer. J Nucl Med 49 Suppl 2:180S-95S
Lewis, Eric M; Singla, Manav; Sergeant, Susan et al. (2008) X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel CYBB mutation and late presentation. Clin Immunol 129:372-80
Joyner, J; Neves, L A A; Stovall, K et al. (2008) Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats. Am J Physiol Regul Integr Comp Physiol 294:R1073-80
Weaver, Kelly L; Ivester, Priscilla; Chilton, Joshua A et al. (2008) The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish. J Am Diet Assoc 108:1178-85
Loeser, Richard F; Erickson, Elizabeth A; Long, David L (2008) Mitogen-activated protein kinases as therapeutic targets in osteoarthritis. Curr Opin Rheumatol 20:581-6
Joyner, J; Neves, L A A; Granger, J P et al. (2007) Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol 293:R169-77