This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health &Science University. This interdisciplinary program brings together 156 faculty from five basic science departments (Biochemistry and Molecular Biology;Cell and Developmental Biology;Molecular and Medical Genetics;Molecular Microbiology and Immunology;and Physiology and Pharmacology), the Cancer Biology Program and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support stipends for 7 Ph.D. students out of the 115 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students directly participate in ground-breaking translational research, ranging from establishment of new therapies that improve cancer survival to new insights into stem cell biology, the molecular basis of neurogenesis and energy homeostasis, protein structure and chemical biology, and vaccine development. Our program offers qualified students a common, rigorous didactic grounding for the first year and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provides a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic sciences.

Public Health Relevance

The studies proposed in this application will provide training for first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists in biomedical sciences. Trainees will learn state-of-the-art methods so that they may participate in ground-breaking basic and bench-to-bedside research that will improve the quality of healthcare in the future.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Hobbs, Samuel J; Osborn, Jossef F; Nolz, Jeffrey C (2018) Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus. Curr Opin Virol 28:12-19
Van Winkle, Jacob A; Robinson, Bridget A; Peters, A Mack et al. (2018) Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells. Cell Host Microbe 24:665-676.e4
Risom, Tyler; Langer, Ellen M; Chapman, Margaret P et al. (2018) Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer. Nat Commun 9:3815
Watanabe-Smith, Kevin; Godil, Jamila; Agarwal, Anupriya et al. (2017) Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: findings and recommendations. Oncotarget 8:12596-12606
Hobbs, Samuel J; Nolz, Jeffrey C (2017) Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans. Front Immunol 8:600
Earley, Lauriel F; Powers, John M; Adachi, Kei et al. (2017) Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11. J Virol 91:
Wu, Yi; Fortin, Dale A; Cochrane, Veronica A et al. (2017) NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic ?-cells. J Biol Chem 292:15512-15524
Watanabe-Smith, K; Tognon, C; Tyner, J W et al. (2016) Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia. Leukemia 30:1950-3
Schafer, Christopher T; Fay, Jonathan F; Janz, Jay M et al. (2016) Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state. Proc Natl Acad Sci U S A 113:11961-11966
Lazelle, Rebecca A; McCully, Belinda H; Terker, Andrew S et al. (2016) Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. J Am Soc Nephrol 27:1456-64

Showing the most recent 10 out of 120 publications