The Cellular and Molecular Pathology (CMP) Graduate Training Program is a joint venture of the University of Wisconsin (UW)-Madison Graduate School, the Department of Pathology & Lab Medicine and the School of Medicine and Public Health (SMPH). CMP provides rigorous didactic training in fundamental basic biomedical sciences combined with interdisciplinary and innovative training in the pathogenesis of major human diseases. The goal of the CMP program is to create a stimulating and robust intellectual environment for predoctoral training embedded in a dynamic basic and clinical translational research atmosphere in order to develop the skills needed to move biological knowledge toward clinical application. The Program draws 50 PhD and 33 MD/MDPhD funded faculty trainers from 24 departments spanning across the Graduate, Veterinary and Medical Schools and College of Arts and Sciences. We are requesting competitive renewal for training of 8 predoctoral students, 6 non-dissertators (2 MD/PhD) and 2 dissertators. Trainees will be supported by the training grant for no longer than 3 years. Candidates will be selected based on a nominating CMP trainer recommendation, research experiences, commitment to research documented by personal statement, letters of recommendation and the potential to enhance diversity and make significant contributions toward the health-related research needs of our nation. Our curriculum provides interdisciplinary and integrated training in fundamental concepts in modern pathobiology with an emphasis on biochemical, cellular and molecular approaches to the study of human disease, including training in statistics relevant to clinical and translational health-related research. CMP also helps students to develop teaching and leadership skills through committee service, seminar presentation and workshop teaching. We are committed to introducing our trainees to multiple career options and ensuring their successful transition by offering career development advising, courses and workshops and creating individual development plans (IDPs) for each student. The demand for greater accountability for public research expenditures and rapid conversion of basic science advances into clinical applications call for increased integration of medical training into graduate education. The CMP Program provides the fundamental knowledge base, research experience, and understanding of translational clinical research necessary for the success of our graduates.

Public Health Relevance

Graduate science education plays a critical role in the success of the U.S. workforce and economy, attracting and producing a diverse work force of researchers, innovators, educators, and leaders. We developed an innovative graduate program relying on the traditions and experience of one of the oldest pathology training programs in the country, but incorporating novel approaches to introduce medical knowledge into graduate education and facilitate the output of true translational scientists. The Cellular and Molecular Pathology (CMP) graduate training program at the University of Wisconsin provides rigorous didactic training in fundamental basic biomedical sciences combined with interdisciplinary and innovative training in the pathogenesis of major human diseases. The original program was established more than 60 years ago as a program focused on general pathology research and education. According to the 'Commission on Pathways Through Graduate School and Into Careers', 'between 2010 and 2020, about 2.6 million new and replacement jobs are expected to require an advanced degree, with a projected increase for jobs requiring a doctorate or professional degree' (www.pathwaysreport.org). The primary mission of the CMP program is to prepare graduates for productive careers in biomedical and clinical research and education and to position them to make significant contributions toward the health-related research needs of our nation. The CMP Program provides graduate students with interdisciplinary and integrated training in the pathogenesis of human diseases with emphasis on molecular, cellular and biochemical approaches. We seek to increase each individual student's appreciation of how specific disease processes directly impact individual patients, while fostering the application of the student's specific research area to potential new concepts in clinical care and treatment. As basic and clinical sciences have evolved, new approaches to apply multidisciplinary knowledge in the field of medicine are required. The CMP graduate program is unique in that it encompasses both basic and clinical research, thereby providing the highest quality graduate education to the next generation of biomedical scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM081061-07
Application #
9066711
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Cole, Alison E
Project Start
2010-07-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
7
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Pathology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Gimse, Kirstan; Gorzek, Ryan C; Olin, Andrew et al. (2018) Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression. Neurobiol Learn Mem 156:17-23
Sutton, Matthew S; Ellis-Connell, Amy; Moriarty, Ryan V et al. (2018) Acute-Phase CD4+ T Cell Responses Targeting Invariant Viral Regions Are Associated with Control of Live Attenuated Simian Immunodeficiency Virus. J Virol 92:
Brown, Matthew E; Zhou, Ying; McIntosh, Brian E et al. (2018) A Humanized Mouse Model Generated Using Surplus Neonatal Tissue. Stem Cell Reports 10:1175-1183
McDaniel, Nellie K; Cummings, Christopher T; Iida, Mari et al. (2018) MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents. Mol Cancer Ther 17:2297-2308
Schmidt, Jenna Kropp; Block, Lindsey N; Golos, Thaddeus G (2018) Defining the rhesus macaque placental miRNAome: Conservation of expression of placental miRNA clusters between the macaque and human. Placenta 65:55-64
Contreras, Amanda; Beems, Megan V; Tatar, Andrew J et al. (2018) Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model. J Immunother Cancer 6:41
Mohr, Emma L; Block, Lindsey N; Newman, Christina M et al. (2018) Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection. PLoS One 13:e0190617
Maes, Margaret E; Schlamp, Cassandra L; Nickells, Robert W (2017) Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis. PLoS One 12:e0184434
Hope, Chelsea; Emmerich, Philip B; Papadas, Athanasios et al. (2017) Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer. J Immunol 199:1933-1941
Nickells, Robert W; Schmitt, Heather M; Maes, Margaret E et al. (2017) AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury. Invest Ophthalmol Vis Sci 58:6091-6104

Showing the most recent 10 out of 84 publications