This application is to support a new interdepartmental graduate program in Translational Biology and Molecular Medicine (TBMM) at Baylor College of Medicine (BCM). The TBMM program was founded in 2004 based on the strategic plan of the college to establish new interdisciplinary programs that will drive a new model of integration of biomedical research, clinical patient care and education. The first TBMM class matriculated in August of 2005 and currently there are 42 TBMM students. The program has over 100 participating faculty from 8 basic and 11 clinical science departments. The major goal of the TBMM program is to train a new cadre of biomedical PhD scientists to work at the interface of basic and clinical research. To train PhD scientists who can more effectively exploit the findings of basic biomedical research to improve human health, we have: (1) designed a unique PhD program with an innovative curriculum and dual mentorship by a basic science mentor and a clinical mentor of research projects that incorporate biomedical sciences with pathophysiology and medical principles. (2) Recruited students to fill the national need for investigators performing translational research at the interface between basic and clinical medicine;and (3) promoted interdisciplinary translational research through student-driven collaborations between basic and clinical science mentors. We expect to graduate PhDs with a solid education in basic science, pathophyisiology and clinical translational research, who are prepared to lead translational research projects. Based on our growing applicant pool and current student body, we are requesting a total of 8 funded positions for years 1-3 with an increase to 10 funded positions for years 4 and 5 of this first award period. This funding will support students in their second and third years of training when they are involved in clinical training as well as pursuing their translational thesis research projects. This funding will allow the TBMM program to mature and document ways to promote effective interactions between basic and clinical investigators and to successfully train a new type of PhD graduate to fill the national need to lead future translational research programs.

Public Health Relevance

This program will train a new generation of biomedical scientists capable of interfacing bench research with clinical medicine. This new PhD awarding interdepartmental graduate program is promoting cross- pollination of science with clinical medicine and influencing all graduate training at Baylor by offering new courses, demonstrating the advantages of dual mentorship, and providing mechanisms for interfaces with the clinical arena.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM088129-03
Application #
8291297
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Cole, Alison E
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$229,011
Indirect Cost
$12,735
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Jayaraman, Padmini; Parikh, Falguni; Newton, Jared M et al. (2018) TGF-?1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy. Oncoimmunology 7:e1490853
Thirumavalavan, Nannan; Scovell, Jason M; Balasubramanian, Adithya et al. (2018) The Impact of Microsurgical Repair of Subclinical and Clinical Varicoceles on Total Motile Sperm Count: Is There a Difference? Urology 120:109-113
Albrecht, Nicholas E; Alevy, Jonathan; Jiang, Danye et al. (2018) Rapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep 24:2506-2519
Lei, Jonathan T; Shao, Jieya; Zhang, Jin et al. (2018) Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Rep 24:1434-1444.e7
Krzykawska-Serda, Martyna; Ho, Jason Chak-Shing; Ware, Matthew J et al. (2018) Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy. Transl Oncol 11:864-872
Newton, Jared M; Hanoteau, Aurelie; Sikora, Andrew G (2018) Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors. J Vis Exp :
Call, Lee; Stoll, Barbara; Oosterloo, Berthe et al. (2018) Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC. Microbiome 6:111
Tanner, Mark R; Pennington, Michael W; Chamberlain, Brayden H et al. (2018) Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. J Pharmacol Exp Ther 365:227-236
Matsunuma, Ryoichi; Chan, Doug W; Kim, Beom-Jun et al. (2018) DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer. Proc Natl Acad Sci U S A 115:E11978-E11987
Scovell, Jason M; Khera, Mohit (2018) Testosterone Replacement Therapy Versus Clomiphene Citrate in the Young Hypogonadal Male. Eur Urol Focus 4:321-323

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