The goal of the proposed Anesthesiology Research Training Program is to develop competent investigative anesthesiologists and basic scientists suitable for entry-level, full-time, academic faculty positions and to prepare these individuals fo productive academic careers including the ability to acquire extramural funding. This subset of investigators will meet the research needs of the specialty of anesthesiology and perioperative medicine in the future including the training of other academic anesthesiologists. The Program is designed to provide laboratory research training: for postdoctoral fellows who have completed their clinical anesthesiology residency or are performing clinical fellowships (Research Track 1: traditional); those residents who are participating in the integrated research and clinical track (Research Track 2: integrated); or outstanding PhD scientists (Research Track 3: basic scientist) with a clear commitment to basic research in anesthesiology. Three to five fellows will spend at least two years cumulative time in research in one of a variety of laboratories in the Department of Anesthesiology or in allied basic science departments. Program faculty consist of 27 potential mentors with diverse research programs (e.g. molecular genetics, angiogenesis, ion channels, cell physiology, adhesion molecules, eicosanoids, exercise and respiratory physiology, hypertension, autonomic nervous system, nitric oxide synthase, nociception, chronic pain, neuroscience, cardioprotection, cerebral circulation, sickle cell disease). The trainees will have access to the facilities of the individual mentors who have been selected because of a keen interest in research training of physician and basic scientists, productivity and extramural support. The two year commitment will include a didactic core curriculum offered through the Division of Graduate Studies of the Medical College of Wisconsin and within the department of Anesthesiology, including the Clinical and Translational Science Institute course Methods in Grant Preparation. The training will occur in an environment that fosters the conduct of translational investigations through collaborations between basic and physician scientists. Recruitment of candidates with diversity enrollment as a priority will focus on those individuals dedicated to a career in academic medicine and demonstrating a superior past performance in medical and postgraduate education and experience in research. These individuals will provide the leadership envisioned for anesthesiology and perioperative medicine in the future and extend the foundation of knowledge serving as a scientific base for the medical subspecialty of anesthesiology.

Public Health Relevance

A growing number of Americans with chronic illness will require anesthesia and surgery. Despite this need, there has been an ominous national decline in the number of physician-scientists participating in basic and clinical research that could address anticipated challenges in perioperative medicine. The purpose of this Training Grant is to provide a subset of outstanding MD and PhD investigators trained to conduct precise and impeccable research of relevance to anesthesiology and perioperative medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM089586-09
Application #
9485946
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Cole, Alison E
Project Start
2010-07-01
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
9
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Liu, Xiaolin; Lauer, Kathryn K; Ward, B Douglas et al. (2018) Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness. Brain Imaging Behav :
Widlansky, Michael E; Jensen, David M; Wang, Jingli et al. (2018) miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. EMBO Mol Med 10:
Malik, Mobin; Suboc, Tisha M; Tyagi, Sudhi et al. (2018) Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res 123:1091-1102
Xiang, Hongfei; Liu, Zhen; Wang, Fei et al. (2017) Primary sensory neuron-specific interference of TRPV1 signaling by AAV-encoded TRPV1 peptide aptamer attenuates neuropathic pain. Mol Pain 13:1744806917717040
Widlansky, Michael E; Puppala, Venkata K; Suboc, Tisha M et al. (2017) Impact of DPP-4 inhibition on acute and chronic endothelial function in humans with type 2 diabetes on background metformin therapy. Vasc Med 22:189-196
Liu, Xiaolin; Lauer, Kathryn K; Douglas Ward, B et al. (2017) Propofol attenuates low-frequency fluctuations of resting-state fMRI BOLD signal in the anterior frontal cortex upon loss of consciousness. Neuroimage 147:295-301
Liu, Xiaolin; Lauer, Kathryn K; Ward, B Douglas et al. (2017) Fine-Grained Parcellation of Brain Connectivity Improves Differentiation of States of Consciousness During Graded Propofol Sedation. Brain Connect 7:373-381
Pillay, Sara B; Binder, Jeffrey R; Humphries, Colin et al. (2017) Lesion localization of speech comprehension deficits in chronic aphasia. Neurology 88:970-975
Fisher, J B; Pulakanti, K; Rao, S et al. (2017) GATA6 is essential for endoderm formation from human pluripotent stem cells. Biol Open 6:1084-1095
Fernandino, Leonardo; Binder, Jeffrey R; Desai, Rutvik H et al. (2016) Concept Representation Reflects Multimodal Abstraction: A Framework for Embodied Semantics. Cereb Cortex 26:2018-34

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