1. The Chemical Biology Training Program at Stony Brook University (SBU) provides graduate students with the training required to make major contributions to the health and welfare of the United States. Students in the training program are selected from four participating graduate programs: the Biochemistry & Structural Biology, the Chemistry, the Molecular Genetics & Microbiology, and the Molecular & Cellular Pharmacology graduate programs. Participating faculty mentors (33) have research interests in infectious disease, cancer, toxicology, immunology, developmental biology, energy-harvesting, cell-signaling, organic synthesis, physical organic chemistry, enzymology, and materials chemistry. Trainees are educated in the principles and techniques of both chemistry and biology with a core interdisciplinary three-semester Chemical Biology course sequence. Activities specific to the CBTP enhance the curriculum with multiple professional development and networking opportunities. These include the Institute of Chemical Biology and Drug Discovery annual symposium and poster session, attended by all trainees and mentors, workshops for the development of trainees' communication skills in collaboration with the Alan Alda Center for Communicating Science, internships, career discussions with alumni, monthly lunches attended by trainees and faculty, and activities at the New York Academy of Sciences. These activities foster extensive interactions between students and faculty and ensure that the trainee group maintains a cohesive identity. The students attend a monthly lunch meeting with a Program Director and faculty mentors as a forum for feedback on careers, program assessment, refresher training in the responsible conduct of research, and to give research presentations. Trainees participate in their home graduate program research clubs and seminar series to broaden their knowledge and networking opportunities beyond the training program. Trainees work with the Alan Alda Center for Communicating Science to formulate research presentations that can reach a variety of audiences. These compelling talks are taken into high needs local high schools in which students have limited access to scientific research in order to foster increased interest and understanding of science. Outside seminar speakers in Chemical Biology are invited to Stony Brook through a variety of forums. Initial instruction in the responsible conduct of research is carried out primarily through participation the course, Scientific Integrit. Recruitment of underrepresented groups is achieved through the SBU Center for Inclusive Education undergraduate research programs and extensive outreach. Six funded positions are requested per year and these positions will be matched by 1.5 institutional training slots.
The Chemical Biology Training Program at Stony Brook University (SBU) provides graduate students with the training required to make major contributions to the health and welfare of the United States. The program trains students to work at the interface of chemistry and biology and to apply quantitative skills to solve biomedical problems. The training program provides students with skills to communicate the significance of their work to the public, and provides a venue for discussing career plans and developing plans to successfully pursue their chosen career path. Training in chemical biology provides graduate students with the chemical and biological methods necessary for developing new and improved diagnostics and therapeutics.
|Laptenok, Sergey P; Gil, Agnieszka A; Hall, Christopher R et al. (2018) Infrared spectroscopy reveals multi-step multi-timescale photoactivation in the photoconvertible protein archetype dronpa. Nat Chem 10:845-852|
|Victor, Tiffany W; Easthon, Lindsey M; Ge, Mingyuan et al. (2018) X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15?nm Beam. Sci Rep 8:13415|
|Roth, Eric; Frohman, Michael A (2018) Proliferative and metastatic roles for Phospholipase D in mouse models of cancer. Adv Biol Regul 67:134-140|
|Guo, Jiaye; Collins, Stephen; Miller, W Todd et al. (2018) Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring. Biochemistry 57:4934-4951|
|Kumar, Pratik; Jiang, Ting; Zainul, Omar et al. (2018) Lipidated cyclopropenes via a stable 3-N spirocyclopropene scaffold. Tetrahedron Lett 59:3435-3438|
|Zhang, Zhuo; Ordonez, Alvaro A; Wang, Hui et al. (2018) Positron Emission Tomography Imaging with 2-[18F]F- p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response. ACS Infect Dis 4:1635-1644|
|Lu, Hao; Iuliano, James N; Tonge, Peter J (2018) Structure-kinetic relationships that control the residence time of drug-target complexes: insights from molecular structure and dynamics. Curr Opin Chem Biol 44:101-109|
|Hossain, Sajjad; Heckler, Ilana; Boon, Elizabeth M (2018) Discovery of a Nitric Oxide Responsive Quorum Sensing Circuit in Vibrio cholerae. ACS Chem Biol 13:1964-1969|
|Williams, Dominique E; Nisbett, Lisa-Marie; Bacon, Bezalel et al. (2018) Bacterial Heme-Based Sensors of Nitric Oxide. Antioxid Redox Signal 29:1872-1887|
|Preston, Alyssa N; Farr, Joshua D; Tan, Kevin C et al. (2018) Design principles for cationic, astrocyte-targeted probes. Chembiochem :|
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