The objective of this program is to train an outstanding pool of graduate students to carry out independent research at the forefront of chemical biology, using concepts and experimental approaches drawn from many areas of chemistry and biology. It is our hope and expectation that these graduate students will emerge from their training to be among the scientific leaders of the future. The training program offers an extraordinary range of training opportunities in chemical biology. Faculty members at Harvard's Cambridge campus including those in the Department of Chemistry and Chemical Biology (CCB) offer world-class expertise in the disciplines spanning organic chemistry and the molecular life sciences, while faculty members at the Harvard Medical School (HMS) offer outstanding strengths at the interface between the molecular life sciences and biomedical problems. In addition, the Broad Institute of Harvard and MIT is a leader in the development of technology to exploit the uses of genomic information, including chemical technologies. The core of our program is a broad, deep and rigorous curriculum. Program students receive core training in kinetics, chemical structure and reactivity as well as the application of thermodynamic concepts in the context of biology. A unifying theme of first year coursework and discussions is the role of chemical tools and approaches in dissecting biological pathways. In addition to the required courses, and depending on their particular interests, students also take elective courses in synthetic organic chemistry, microbiology, cell biology, structural biology, genetics and genomics, proteomics, metabolomics and systems biology. Students are exposed to an unusual range of technologies and concepts in chemical biology through coursework, interactions with faculty and other students, and Program events such as the Program retreat and Student Data Club. In addition, trainees gain teaching experience and receive broad training in responsible conduct of research at different stages of the program. The Program thus represents a mechanism to transfer concepts and technologies from chemistry to biology, medicine and genomics and vice versa.

Public Health Relevance

Chemical biology is a key link between the basic discovery efforts of biology labs and the drug development efforts of pharmaceutical and biotechnology companies. This program trains students in the chemical tools and approaches used to address problems in human health, including chemical synthesis, natural product chemistry, mass spectrometry (metabolomics, proteomics), high throughput screening, and microscopy, including state-of-the-art single molecule methods.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
7T32GM095450-07
Application #
9306908
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Fabian, Miles
Project Start
2011-07-01
Project End
2021-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
University-Wide
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Koblan, Luke W; Doman, Jordan L; Wilson, Christopher et al. (2018) Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol 36:843-846
Wachnowsky, C; Fidai, I; Cowan, J A (2018) Iron-sulfur cluster biosynthesis and trafficking - impact on human disease conditions. Metallomics 10:9-29
Waldman, Abraham J; Ng, Tai L; Wang, Peng et al. (2017) Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis. Chem Rev 117:5784-5863
Wesley, Nathaniel A; Wachnowsky, Christine; Fidai, Insiya et al. (2017) Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1. FEBS J 284:3838-3848
Wesley, Nathaniel A; Wachnowsky, Christine; Fidai, Insiya et al. (2017) Analysis of NFU-1 metallocofactor binding-site substitutions-impacts on iron-sulfur cluster coordination and protein structure and function. FEBS J 284:3817-3837
Nakayama, Robert T; Pulice, John L; Valencia, Alfredo M et al. (2017) SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat Genet 49:1613-1623
Komor, Alexis C; Zhao, Kevin T; Packer, Michael S et al. (2017) Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv 3:eaao4774
Remillard, David; Buckley, Dennis L; Paulk, Joshiawa et al. (2017) Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl 56:5738-5743
Wachnowsky, Christine; Wesley, Nathaniel A; Fidai, Insiya et al. (2017) Understanding the Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1)-Impact of a Disease-Causing Gly208Cys Substitution on Structure and Activity of NFU1 in the Fe/S Cluster Biosynthetic Pathway. J Mol Biol 429:790-807
Wachnowsky, Christine; Fidai, Insiya; Cowan, J A (2016) Iron-sulfur cluster exchange reactions mediated by the human Nfu protein. J Biol Inorg Chem 21:825-836

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