Given WFUSM's outstanding international reputation in the fields of trauma and regenerative medicine, we propose to initiate a new training program titled Integrative Training in Trauma and Regenerative Medicine for MD Investigators. This program will focus on the application of basic science discoveries in regenerative medicine to the treatment of trauma and burn patients. Key features of this program will include completion of the MS degree in Molecular Medicine and Translational Sciences, benchtop research in regenerative medicine, and joint mentorship with both clinical and basic science faculty. The ultimate goal of this training grant is to attrac and train a cohort of outstanding physician-scientists who will be able to translate the latest developments in regenerative medicine research into clinical care for trauma and burn patients. The proposed training program will rely on the longstanding and productive multidisciplinary collaborations of faculty members from General Surgery, Orthopedics, Plastic Surgery, Regenerative Medicine, and the Wake Forest University Translational Science Institute (WFU TSI). The program will also be supported by other key institutional resources associated with the MS degree program in Molecular Medicine and Translational Sciences, which are described in this application. The independent research projects required for the MS degree will be facilitated by access to faculty members from the basic science and clinical faculty.
Trauma is the leading cause of death in the United States for individuals ages 1 to 44 years, and the resultant loss of productive lifeyears is greater than from any other single cause. Although the vast majority of patients survive their injuris, some suffer significant morbidity. The training program proposed herein will seek to train physician-scientists in the field of regenerative medicine as it relates to the management of patients suffering from multisystem trauma and burns.
| Zhou, Yu; Lovell, Daniel; Bethea, Maigen et al. (2017) * The Impact of Age on Skeletal Muscle Progenitor Cell Survival and Fate After Injury. Tissue Eng Part C Methods 23:1012-1021 |
| Luo, T David; Alton, Timothy B; Apel, Peter J et al. (2016) Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury. Muscle Nerve 54:769-75 |
| Vossler, John D; Min Ju, Young; Williams, J Koudy et al. (2015) CD133 antibody conjugation to decellularized human heart valves intended for circulating cell capture. Biomed Mater 10:055001 |
