The training program, open to physicians (MD or MD/PhD)during their residency training or as a post- graduate research fellowship and to basic scientists (PhD) early in their research career, is designed to provide 2 years of research training in perioperative science. The major goal of this training program is to provide the highest caliber research training in four Specific Themes originating from existing strengths of our faculty at Vanderbilt University Medical Center. The Research Themes include: 1) Mechanisms and Management of Pain;2) Perioperative Stress Biology and Outcomes;3) Perioperative Health Services and Translational Research;and 4) Personalized Medicine and Pharmacogenomics. Each of these themes directly relates to the overarching aim of the program - to train the next generation of scientists to create new knowledge and translate it into best evidence for personalized perioperative care and pain management at a population level. The training faculty will consist of an exceptionally strong collection of physician-scientists and basic scientists who offer superb interdisciplinary research training opportunities in 7 different academic departments. The training program will accept three new trainees per year (maximum 6 participants per year) with ratios depending on availability: 4 clinicians and 2 PhDs or 3 clinicians and 3 Ph.Ds. Clinicians who show exceptional aptitude for successfully pursuing an academic research career and Ph.D. scientists who demonstrate the best aptitude to develop towards independence will be considered for participation. Each participant will commit to a 2 year basic science, clinical and/or translational research project with 75% effort for Clinicians and 100% effort for PhDs. In addition to their research project training, trainees will receive coursework instruction in research related processes such grant writing, publications, ethics, and responsible conduct of research. This training will prepare them to utilize the skills they acquire in the pursuit of future academic research careers.

Public Health Relevance

This training program in basic, clinical, and translational research will train basic and physician scientists in mechanisms and management of pain, perioperative stress biology and outcomes, health service and translational research, and personalized medicine and pharmacogenomics. The program will prepare future researchers for the unique challenges associated with the optimization of perioperative care.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1)
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Cole, Alison E
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Vanderbilt University Medical Center
Schools of Medicine
United States
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Cummings, Jared J; Shaw, Andrew D; Shi, Jing et al. (2018) Intraoperative prediction of cardiac surgery-associated acute kidney injury using urinary biomarkers of cell cycle arrest. J Thorac Cardiovasc Surg :
McNeil, J Brennan; Shaver, Ciara M; Kerchberger, V Eric et al. (2018) Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 197:1027-1035
Hubers, Scott A; Wilson, Jessica R; Yu, Chang et al. (2018) DPP (Dipeptidyl Peptidase)-4 Inhibition Potentiates the Vasoconstrictor Response to NPY (Neuropeptide Y) in Humans During Renin-Angiotensin-Aldosterone System Inhibition. Hypertension 72:712-719
Janz, David R; Semler, Matthew W; Joffe, Aaron M et al. (2018) A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults. Chest 153:816-824
Brittain, Evan L; Duncan, Meredith S; Chang, Joyce et al. (2018) Increased Echocardiographic Pulmonary Pressure in HIV-infected and -uninfected Individuals in the Veterans Aging Cohort Study. Am J Respir Crit Care Med 197:923-932
Bruehl, Stephen; Burns, John W; Morgan, Amanda et al. (2018) The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids. Pain :
Semler, Matthew W; Janz, David R; Russell, Derek W et al. (2017) A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults. Chest 152:712-722
Smith, Loren E; Smith, Derek K; Blume, Jeffrey D et al. (2017) High-Density Lipoprotein Cholesterol Concentration and Acute Kidney Injury After Cardiac Surgery. J Am Heart Assoc 6:
O'Neal, Jason B; Billings 4th, Frederic T; Liu, Xulei et al. (2017) Effect of Preoperative Beta-Blocker Use on Outcomes Following Cardiac Surgery. Am J Cardiol 120:1293-1297
O'Neal, Jason B; Billings 4th, Frederic T; Liu, Xulei et al. (2017) Risk factors for delirium after cardiac surgery: a historical cohort study outlining the influence of cardiopulmonary bypass. Can J Anaesth 64:1129-1137

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