This is an application for renewal of an Institutional Research Training Grant within the Department of Pediatrics at Washington University School of Medicine. The long-term objective is to foster the growth and development of pediatric physician-scientists who are prepared to pursue independent academic careers investigating important issues in childhood infection and immunity.
The specific aim of this proposal is to utilize the unique resources of the institution, including the Center for Infectious Diseases Research, the Center for Immunology, and the Division of General Medical Sciences, to maintain a training program with a participating faculty of pediatricians, basic scientists, and clinical investigators who share common interests and Frequent investigative and scholarly interactions. The program is intended to provide funding for an initial two years of investigation and emphasizes the application of cell and molecular biologic approaches and rigorous clinical and epidemiologic methods to address common issues in childhood infection and immunity. Trainees will have access to sufficient space and resources and will benefit from the numerous educational activities within the institution, including didactic coursework, journal clubs, and relevant seminars. The program director will utilize an executive committee to select candidate trainees, to review the scholarly progress of trainees, and to obtain continuing advice with respect to operation of the program. The substantial collaboration of established pediatric physician-scientists and basic and clinical investigators in other departments pursuing questions in microbial pathogenesis, immunology, and clinical infectious diseases provides a unique opportunity for the training of selected individuals in the application of experimental methods to the treatment and prevention of infectious and immunologic diseases in children. As such, this program should foster the development of new pediatric scholars to lead the way for future advances in these important areas of child health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
2T32HD007507-06
Application #
6592726
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (32))
Program Officer
Lock, Allan
Project Start
1998-05-01
Project End
2008-04-30
Budget Start
2003-07-11
Budget End
2004-04-30
Support Year
6
Fiscal Year
2003
Total Cost
$233,374
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Fritz, Stephanie A; Krauss, Melissa J; Epplin, Emma K et al. (2011) The natural history of contemporary Staphylococcus aureus nasal colonization in community children. Pediatr Infect Dis J 30:349-51
Ramachandran, Rajesh; Zhao, Xiao-Feng; Goldman, Daniel (2011) Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Proc Natl Acad Sci U S A 108:15858-63
Ramachandran, Rajesh; Fausett, Blake V; Goldman, Daniel (2010) Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol 12:1101-7
Ramachandran, Rajesh; Reifler, Aaron; Parent, Jack M et al. (2010) Conditional gene expression and lineage tracing of tuba1a expressing cells during zebrafish development and retina regeneration. J Comp Neurol 518:4196-212
Loughman, Jennifer A; Fritz, Stephanie A; Storch, Gregory A et al. (2009) Virulence gene expression in human community-acquired Staphylococcus aureus infection. J Infect Dis 199:294-301
Riddle, David J; Dubberke, Erik R (2009) Clostridium difficile infection in the intensive care unit. Infect Dis Clin North Am 23:727-43
Dubberke, E R; Riddle, D J; AST Infectious Diseases Community of Practice (2009) Clostridium difficile in solid organ transplant recipients. Am J Transplant 9 Suppl 4:S35-40
Fritz, Stephanie A; Epplin, Emma K; Garbutt, Jane et al. (2009) Skin infection in children colonized with community-associated methicillin-resistant Staphylococcus aureus. J Infect 59:394-401
Weston, Benjamin F; Brenot, Audrey; Caparon, Michael G (2009) The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infect Immun 77:2840-8
Fritz, Stephanie A; Garbutt, Jane; Elward, Alexis et al. (2008) Prevalence of and risk factors for community-acquired methicillin-resistant and methicillin-sensitive staphylococcus aureus colonization in children seen in a practice-based research network. Pediatrics 121:1090-8

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