This is a revised application for an institutional training grant for pediatric physician-scientists that will be centered in the Department of Medicine, Children's Hospital Boston. It is intended to support the postdoctoral training of pediatricians who will continue on to careers in academic pediatrics. Five postdoctoral positions per year are requested, for each of five years. Trainees will each train for an average of two years. The training faculty consist of 30 senior academic and scientific leaders at Children's Hospital, including all 13 Division Chiefs. Trainees will be selected, using rigorous and well-defined criteria, from those in clinical and research subspecialty fellowship training programs within the 13 Divisions within the Department of Medicine. They will take advantage of a supportive environment anchored by a Fellowship Program Office and an Office of Faculty Development (which also assists all other postdoctoral fellows at Children's Hospital Boston). All trainees will take an established course in research methods hosted by the Clinical Research Program of Children's Hospital. Trainees will pursue one of two tracks. Those in the clinical research track will receive didactic instruction at the Harvard School of Public Health in clinical research methods, with the choice of receiving an M.P.H. Those involved in laboratory research will take courses in molecular biology and genetics as well as biostatistics. All trainees will receive instruction in ethical scientific conduct. The proposed mentors have a strong track record in training pediatrician-scientists alongside PhD, non-MD scientists: during the past decade, they have trained 432 MDs and 314 PhDs. Of the 432 MDs, over 186 are productive academic physician-scientists, 140 of whom are pediatricians. Of these, 13, 23, and 85 are at the academic level of professor, associate professor, and assistant professor, respectively. There are 29 Department Chairs or Division/Section Chiefs among them. These former trainees currently hold in aggregate 86 NIH grants and have themselves trained over 285 second-generation trainees (including 18 professors, 37 associate professors, and 62 assistant professors). This training grant offers the opportunity to bring an increasing number of pediatricians into rigorous clinical and bench training environments under the direction of proven mentors, so that they can contribute to the next generation of academic pediatrician scientists. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
1T32HD043034-01A1
Application #
6659448
Study Section
Special Emphasis Panel (ZHD1-DSR-A (19))
Program Officer
Huang, Terry T-K
Project Start
2003-06-01
Project End
2008-04-30
Budget Start
2003-06-01
Budget End
2004-04-30
Support Year
1
Fiscal Year
2003
Total Cost
$246,194
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Mei, Zhengrong; Qiu, Jianhua; Alcon, Sasha et al. (2018) Memantine improves outcomes after repetitive traumatic brain injury. Behav Brain Res 340:195-204
Gallagher, Jenny Sadler; Missmer, Stacey A; Hornstein, Mark D et al. (2018) Long-Term Effects of Gonadotropin-Releasing Hormone Agonists and Add-Back in Adolescent Endometriosis. J Pediatr Adolesc Gynecol 31:376-381
Sadler Gallagher, Jenny; Feldman, Henry A; Stokes, Natalie A et al. (2017) The Effects of Gonadotropin-Releasing Hormone Agonist Combined with Add-Back Therapy on Quality of Life for Adolescents with Endometriosis: A Randomized Controlled Trial. J Pediatr Adolesc Gynecol 30:215-222
DiVasta, Amy D; Feldman, Henry A; Sadler Gallagher, Jenny et al. (2015) Hormonal Add-Back Therapy for Females Treated With Gonadotropin-Releasing Hormone Agonist for Endometriosis: A Randomized Controlled Trial. Obstet Gynecol 126:617-27
Duro, Debora; Mitchell, Paul D; Mehta, Nilesh M et al. (2014) Variability of resting energy expenditure in infants and young children with intestinal failure-associated liver disease. J Pediatr Gastroenterol Nutr 58:637-41
Duro, Debora; Mitchell, Paul D; Kalish, Leslie A et al. (2011) Risk factors for parenteral nutrition–associated liver disease following surgical therapy for necrotizing enterocolitis: A Glaser Pediatric Research Network Study [corrected]. J Pediatr Gastroenterol Nutr 52:595-600
Duro, Debora; Kalish, Leslie A; Johnston, Patrick et al. (2010) Risk factors for intestinal failure in infants with necrotizing enterocolitis: a Glaser Pediatric Research Network study. J Pediatr 157:203-208.e1
Duro, Debora; Fitzgibbons, Shimae; Valim, Clarissa et al. (2010) [13C]Methionine breath test to assess intestinal failure-associated liver disease. Pediatr Res 68:349-54
Duro, Debora; Duggan, Christopher; Valim, Clarissa et al. (2009) Novel intravenous (13)C-methionine breath test as a measure of liver function in children with short bowel syndrome. J Pediatr Surg 44:236-40; discussion 240
Duro, Debora; Kamin, Daniel; Duggan, Christopher (2008) Overview of pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 47 Suppl 1:S33-6

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