This application requests support for 2 physician training positions for 3rd and 4th year neonatology fellows, which will allow them to develop the knowledge, understanding and skills needed to pursue independent research careers in academic neonatology. Two major academic research paths will be available to trainees, and each track will be associated with a specific curriculum containing required course work: Track I. Basic Research, Physician-Scientist (laboratory research mentorship), and Track II. Clinical Research, Physician-Scientist (clinical research mentorship) which includes Health Care Policy and Medical Informatics mentorship components. This program with its two research tracks resides with the Division of Neonatology which includes: five clinical research physician-scientists (two of whom are Masters trained); two basic research physician-scientists; ten Ph.D.s; and the Neonatal-Perinatal Research Institute (NPRI). The NPRI includes sixty-five senior investigators, forty of whom are NIH funded, and draws upon the academic strength and depth found across Duke University needed to support the formal training for the program in developmental biology, clinical sciences and health care research. Extramurally funded research within the NPRI currently supports 4 broad areas of investigation: 1) early cardio/cranio/facia development; 2) neonatal lung development/repair; 3) neural injury and repair in the fetus and neonate; and 4) clinical neonatal research in conjunction with the NICHD Neonatal Network and the Duke Clinical Research Institute. In addition, this grant proposes a unique program with curricula for the study of Health Care Policy and Medical Informatics in the context of a medical research career. The requested funds will provide critical support for the research years of the neonatology fellowship, which currently trains six to seven fellows at Duke University Medical Center. The unique research training program with its separate Tracks will provide a structured learning experience tailored to the needs and interests of the individual fellow, with each fellow working with a senior scientist who will serve as mentor. Upon completion of the training program, the young physician-scientist will have the tools, knowledge, experience and confidence to compete successfully as an independent investigator.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
1T32HD043728-01A2
Application #
6894871
Study Section
Special Emphasis Panel (ZHD1-DSR-A (09))
Program Officer
Raju, Tonse N
Project Start
2005-05-01
Project End
2010-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
1
Fiscal Year
2005
Total Cost
$142,600
Indirect Cost
Name
Duke University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Thompson, Elizabeth J; Greenberg, Rachel G; Kumar, Karan et al. (2018) Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight. J Pediatr 199:231-236
Heath, Travis S; Greenberg, Rachel G; Hupp, Susan R et al. (2018) Effects of Methadone on Corrected Q-T Interval Prolongation in Critically Ill Children. J Pediatr Pharmacol Ther 23:119-124
Ravisankar, Srikanth; Kuehn, Devon; Clark, Reese H et al. (2017) Antihypertensive drug exposure in premature infants from 1997 to 2013. Cardiol Young 27:905-911
Greenberg, Rachel G; Kandefer, Sarah; Do, Barbara T et al. (2017) Late-onset Sepsis in Extremely Premature Infants: 2000-2011. Pediatr Infect Dis J 36:774-779
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Parente, V; Clark, R H; Ku, L et al. (2017) Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing. J Perinatol 37:157-161
Ku, Lawrence C; Wu, Huali; Greenberg, Rachel G et al. (2016) Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine. Ther Drug Monit 38:728-737
Rudra, Sharmistha; Adibe, Obinna O; Malcolm, William F et al. (2016) Gastrostomy tube placement in infants with congenital diaphragmatic hernia: Frequency, predictors, and growth outcomes. Early Hum Dev 103:97-100
Greenberg, Rachel G; Melloni, Chiara; Wu, Huali et al. (2016) Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach. Clin Neuropharmacol 39:232-40
Younge, Noelle; Smith, P Brian; Gustafson, Kathryn E et al. (2016) Improved survival and neurodevelopmental outcomes among extremely premature infants born near the limit of viability. Early Hum Dev 95:5-8

Showing the most recent 10 out of 21 publications