A Training Program in Organogenesis is being submitted by the Cincinnati Children's Hospital Research Foundation (CCHRF). The program will provide training in organ morphogenesis, dysmorphogenesis, and repair, and is a major focus of research in many different divisions at the CCHRF. This program aims to unify training in organogenesis by bringing together both clinical and basic science faculty and trainees with primary interests in this research discipline. Thirty-five faculty from nine divisions will form the core of mentors in the program. These comprise a mix of clinicians and basic scientists with primary interests in organogenesis. Faculty in the CCHRF hold primary appointments in the departments of Pediatrics (the majority), Surgery, Radiology, and Anesthesiology. In 2004 and the first few months of 2005, this group of training faculty has more than 180 publications, including papers in Nature, Cell, Science, Nature Immunology, Nature Cell Biology, Nature Medicine, Molecular Cell, The Lancet, PNAS, and Development, as well as other premier specialist journals. Trainees in this program will be graduate students, postdoctoral fellows, and clinical fellows in training at CCHRF. Graduate students from three programs in the University (M.D./Ph.D., Molecular and Developmental Biology, and Neurosciences) carry out their training in laboratories in the CCHRF. There are currently 81 postdoctoral fellows in basic science laboratories, and 152 clinical fellows. CCHRF has made a major investment in basic research in recent years, by recruiting new faculty in divisions of Developmental Biology, Pulmonary Biology, Molecular Cardiovascular Biology, Immunology, and Experimental Hematology. The program will dramatically enhance and unify one of the major foci of research at CCHRF, and establish new leaders in this field, at a time when insights into the basic mechanisms of organogenesis can make a real impact on the understanding, diagnosis, and treatment of congenital disorders of organ formation in children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD046387-05
Application #
7847642
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Javois, Lorette Claire
Project Start
2006-05-01
Project End
2011-06-30
Budget Start
2010-05-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$215,490
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Lu, Thomas X; Lim, Eun-Jin; Besse, John A et al. (2013) MiR-223 deficiency increases eosinophil progenitor proliferation. J Immunol 190:1576-82
Lu, T X; Lim, E-J; Wen, T et al. (2012) MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome. Mucosal Immunol 5:388-96
Lu, Thomas X; Sherrill, Joseph D; Wen, Ting et al. (2012) MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers. J Allergy Clin Immunol 129:1064-75.e9
Li-Kroeger, David; Cook, Tiffany A; Gebelein, Brian (2012) Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells. Development 139:1611-9
Du, Aiping; McCracken, Kyle W; Walp, Erik R et al. (2012) Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol 365:175-88
McCracken, Kyle W; Howell, Jonathan C; Wells, James M et al. (2011) Generating human intestinal tissue from pluripotent stem cells in vitro. Nat Protoc 6:1920-8
Charlton-Perkins, Mark; Whitaker, S Leigh; Fei, Yueyang et al. (2011) Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural Dev 6:20
Lu, Thomas X; Hartner, Jochen; Lim, Eun-Jin et al. (2011) MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol 187:3362-73
Johnston Jr, Robert J; Otake, Yoshiaki; Sood, Pranidhi et al. (2011) Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye. Cell 145:956-68
Sipes, Nisha S; Feng, Yuxin; Guo, Fukun et al. (2011) Cdc42 regulates extracellular matrix remodeling in three dimensions. J Biol Chem 286:36469-77

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