): The current era of scientific research is marked by an increasing interest in nutrition and metabolism, as it relates to HIV disease. This interest relates not only to the pathogenesis and clinical implications of obesity, but to role played by adipocytes and adipocyte signaling in modulating hormonal and higher cortical functions in such patients. Critical insights regarding the role of nutrient trafficking in the maintenance of glucose homeostasis, the pathophysiology and molecular basis of atherosclerosis, the profound consequences of abnormal nutrition, and the role of altered nutrition in reproduction and bone development have recently been made using HIV disease as a disease model. Furthermore, nutrition has become a major public health issue in the HIV population, with important effects on cardiovascular disease. Unfortunately, despite the increasing interest in nutrition and metabolism research, there are few established training programs for such research in patients with HIV disease and similar disorders of under and overnutrition. With the development of ever more powerful, but complex tools to study nutrient trafficking (PET and NMR), the genetic basis of diseases (genomics), and targeted treatment strategies (gene therapy), there is an acute need for sophisticated training in nutrition and metabolism, not covered under the rubric of existing programs. The purpose of this new training grant proposal is to train highly qualified M.D.'s and Ph.D's in the sophisticated techniques of clinical and translational nutrition research in the area of HIV disease, utilizing a well established group of mentors at Harvard Medical School, coordinated through the Harvard Division of Nutrition and MGH Program in Nutritional Metabolism. Application of clinical and basic investigation (e.g. nutrient signaling in the brain, the molecular mechanisms of fat redistribution, and the role of tissue specific GLUT-4 receptors) will be emphasized. Furthermore, the program offers opportunities for state of the art epidemiologic research into the public health consequences of obesity and malnutrition in HIV patients. The Faculty at the Harvard Division of Nutrition and the affiliated Hospitals and Schools (MGH, Brigham and Women's, Beth Israel Deaconess Medical Center, Children's Hospital, and the Harvard School of Public Health) are performing novel nutrition-related research and constitute a unique resource for training in nutrition and metabolism related directly to HIV and indirectly, via similar models of altered nutrient trafficking and metabolism. The established training record of the program faculty, broad research and educational opportunities in the Division and affiliated Programs, and rigorous training structure will contribute toward the stated goals of the proposal to train a new generation of investigators in nutrition and metabolism research related to HIV disease.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD052961-05
Application #
7619559
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Raiten, Daniel J
Project Start
2005-09-27
Project End
2011-04-30
Budget Start
2009-05-01
Budget End
2011-04-30
Support Year
5
Fiscal Year
2009
Total Cost
$194,244
Indirect Cost
Name
Harvard University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Farr, Olivia M; Mantzoros, Christos S (2018) Obese individuals with type 2 diabetes demonstrate decreased activation of the salience-related insula and increased activation of the emotion/salience-related amygdala to visual food cues compared to non-obese individuals with diabetes: A preliminary stu Diabetes Obes Metab 20:2500-2503
Braun, Laurie R; Feldpausch, Meghan N; Czerwonka, Natalia et al. (2018) Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial. J Clin Endocrinol Metab 103:4176-4186
Singhal, Vibha; Tulsiani, Shreya; Campoverde, Karen Joanie et al. (2018) Impaired bone strength estimates at the distal tibia and its determinants in adolescents with anorexia nervosa. Bone 106:61-68
Farr, O M; Mantzoros, C S (2017) Obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate decreased activation of reward-related brain centers in response to food cues in both the fed and fasting states: a preliminary fMRI study. Int J Obes (Lond) 41:471-474
Braun, Laurie R; Feldpausch, Meghan N; Czerwonka, Natalia et al. (2017) Fibroblast growth factor 21 decreases after liver fat reduction via growth hormone augmentation. Growth Horm IGF Res 37:1-6
Farr, Olivia M; Upadhyay, Jagriti; Gavrieli, Anna et al. (2016) Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Diabetes 65:2943-53
Farr, Olivia M; Sofopoulos, Michail; Tsoukas, Michael A et al. (2016) GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled Diabetologia 59:954-65
Singhal, Vibha; Miller, Karen K; Torriani, Martin et al. (2016) Short- and long-term reproducibility of marrow adipose tissue quantification by 1H-MR spectroscopy. Skeletal Radiol 45:221-5
Vamvini, Maria T; Hamnvik, Ole-Petter; Sahin-Efe, Ayse et al. (2016) Differential Effects of Oral and Intravenous Lipid Administration on Key Molecules Related to Energy Homeostasis. J Clin Endocrinol Metab 101:1989-97
Mathew, Hannah; Farr, Olivia M; Mantzoros, Christos S (2016) Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients. Metabolism 65:73-80

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