There is a pressing need for an increase in the number of scientists and clinicians in the profession of prosthetics and orthotics with advanced degrees to pursue research and direct the associated clinical education programs. In view of the rise of terroristic warfare, increases in the incidence of diabetes and obesity, and the aging population, the shortage of basic and translational research is limiting critical advances in this field. The purpose of this application is to request a renewal of a successful predoctoral training grant designed to ameliorate the research base of prosthetics and orthotics. In this training program, competent researchers are being trained in the clinically relevant physiological sciences and engineering. The trainees are exposed to the clinical practice of prosthetics and orthotics to better inform the research and to develop sensitivity to the needs of the patients. The students are also educated in the responsible conduct of research and biomedical medical ethics in a problem-based setting. Twenty-three faculty members from basic science and clinical departments and centers from Georgia Institute of Technology, Emory University and Georgia State University and the Shepherd Center constitute the training faculty for this program, which is based in the School of Applied Physiology at Georgia Tech. The School provides a unique setting for this program given that the focus of interest is on movement science. The faculty investigates mechanisms of motor control from molecular through systems and behavioral levels using physiological and engineering approaches. The School is also the home of the first entry-level masters level degree program in prosthetics and orthotics in the United States. The trainees work closely with the students and faculty of this clinical masters program to ensure the clinical relevance of the training. The program includes a core curriculum in physiology, neuroscience and biomechanics, and a seminar in which problems in contemporary rehabilitation sciences are discussed. Courses in rehabilitation related science and technology have been developed with faculty members in the Division of Physical Therapy at Emory. The program is flexible in accommodating students with different backgrounds and different research goals. The program of study lasts from 4-6 years and culminates in the PhD degree from The Georgia Institute of Technology with a focus in prosthetics and orthotics

Public Health Relevance

The purpose of this predoctoral training program is to prepare students for careers in research related to prosthetics and orthotics to meet the needs of a growing and important area of rehabilitation medicine. The program consists of a flexible curriculum in physiological sciences, rehabilitation sciences, and engineering, with exposure to clinical practice and training in ethics and in the responsible conduct of research. The program features an extensive training faculty in clinical and basic research, and close interaction with a clinical master's program in prosthetics and orthotics.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-D (DL))
Program Officer
Nitkin, Ralph M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Georgia Institute of Technology
Schools of Arts and Sciences
United States
Zip Code
Jarrell, Joshua R; Farrell, Brad J; Kistenberg, Robert S et al. (2018) Kinetics of individual limbs during level and slope walking with a unilateral transtibial bone-anchored prosthesis in the cat. J Biomech 76:74-83
Selgrade, Brian P; Toney, Megan E; Chang, Young-Hui (2017) Two biomechanical strategies for locomotor adaptation to split-belt treadmill walking in subjects with and without transtibial amputation. J Biomech 53:136-143
Selgrade, Brian P; Thajchayapong, Montakan; Lee, Gloria E et al. (2017) Changes in mechanical work during neural adaptation to asymmetric locomotion. J Exp Biol 220:2993-3000
Cusack, William F; Thach, Scott; Patterson, Rebecca et al. (2016) Enhanced Neurobehavioral Outcomes of Action Observation Prosthesis Training. Neurorehabil Neural Repair 30:573-82
Toney, Megan E; Chang, Young-Hui (2016) The motor and the brake of the trailing leg in human walking: leg force control through ankle modulation and knee covariance. Exp Brain Res 234:3011-23
Williams, Laura; Pirouz, Nikta; Mizelle, J C et al. (2016) Remodeling of cortical activity for motor control following upper limb loss. Clin Neurophysiol 127:3128-3134
Giest, Tracy N; Chang, Young-Hui (2016) Biomechanics of the human walk-to-run gait transition in persons with unilateral transtibial amputation. J Biomech 49:1757-1764
Lawson, Delisa T; Cusack, William F; Lawson, Regan et al. (2016) Influence of Perspective of Action Observation Training on Residual Limb Control in Naïve Prosthesis Usage. J Mot Behav 48:446-54
Farrell, Brad J; Bulgakova, Margarita A; Sirota, Mikhail G et al. (2015) Accurate stepping on a narrow path: mechanics, EMG, and motor cortex activity in the cat. J Neurophysiol 114:2682-702
Selgrade, Brian P; Chang, Young-Hui (2015) Locomotor control of limb force switches from minimal intervention principle in early adaptation to noise reduction in late adaptation. J Neurophysiol 113:1451-61

Showing the most recent 10 out of 21 publications