This application seeks renewed support for a training program in Vertebrate Developmental Genomics at Cornell University. This program supports the training of 3 predoctoral students who have begun their thesis research. Fifteen faculty will serve as faculty Trainers. They represent a range of expertise including functional genomics, developmental genetics, evolutionary genomics, statistical genetics, reproductive genomics, and genomics of gene regulation, classical embryogenesis, and genetics of developmental disorders. Their research concentrates on vertebrate organisms including mice, zebrafish, chick, and humans. They also provide expertise in several important areas of vertebrate development and disease, including neurobiology, reproductive biology, stem cells, organogenesis, heart disease & function, chromatin structure & function, early post implantation development, evolution of development, epigenetics, nutritional genomics, and cancer. Graduate students in their 2nd year and beyond will be selected from several existing graduate Fields across campus. Selection will be based upon academic and research promise of the student, the quality and relevance of their thesis work in vertebrate developmental genomics, and aspirations to conduct independent research in this area. The training program is augmented by its association with Cornell's Center for Vertebrate Genomics (CVG), which sponsors several activities supportive of graduate training. The 3 trainees form a peer group with ~5 CVG Genomics Scholars who participate in several shared activities but conduct research in diverse areas of genomics. Most trainees will obtain a Minor degree in Genomics, and participate in several activities related to the training theme including: the student/postdoc-organized Vertebrate Genomics Journal Club; the Developmental Biology Journal Club; the VERGE (Vertebrate Genomics) research series; the annual CVG symposium; monthly lunch meetings for informal research discussions and presentations; ethics training; and relevant external conferences and courses. Selection of students and monitoring of their ongoing and postgraduate career progress will be overseen by an Executive committee and Program-assigned mentor, their thesis committee, and an external advisory committee. Coupled with an exceptional tradition of dedication to training academic researchers and targeted Institutional support for Vertebrate Genomics, this program will continue to provide an outstanding environment for Trainees to pursue successful careers in basic or applied research in developmental genomics.

Public Health Relevance

Critical to the understanding of disease and birth defects is a solid comprehension of the underlying molecular and genetic mechanisms of development. These basic mechanisms have been elucidated through the study of many powerful model organisms and extrapolated to humans. This program will provide Trainees with a comprehension and appreciation of the important problems in animal development, and experience in using state-of-the-art genomics tools to address new frontiers in this area.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD057854-08
Application #
9477951
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Coulombe, James N
Project Start
2010-09-01
Project End
2021-04-30
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Cornell University
Department
Other Basic Sciences
Type
Schools of Veterinary Medicine
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Rinaldi, Vera D; Bloom, Jordana C; Schimenti, John C (2018) Whole Mount Immunofluorescence and Follicle Quantification of Cultured Mouse Ovaries. J Vis Exp :
Tippens, Nathaniel D; Vihervaara, Anniina; Lis, John T (2018) Enhancer transcription: what, where, when, and why? Genes Dev 32:1-3
Ghazanfar, Shila; Bisogni, Adam J; Ormerod, John T et al. (2016) Integrated single cell data analysis reveals cell specific networks and novel coactivation markers. BMC Syst Biol 10:127
Taylor, David H; McLean, Chelsea M; Wu, Warren L et al. (2016) Imprinted DNA methylation reconstituted at a non-imprinted locus. Epigenetics Chromatin 9:41
Alexander, Katherine A; Wang, Xu; Shibata, Maho et al. (2015) TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming. Cell Rep 13:1194-1205
Welsh, Ian C; Kwak, Hojoong; Chen, Frances L et al. (2015) Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality. Cell Rep 13:337-49
McElwee, John L; Mohanan, Sunish; Horibata, Sachi et al. (2014) PAD2 overexpression in transgenic mice promotes spontaneous skin neoplasia. Cancer Res 74:6306-17
Wallace, M D; Southard, T L; Schimenti, K J et al. (2014) Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress. Oncogene 33:3688-95
Mahadevan, Aparna; Welsh, Ian C; Sivakumar, Aravind et al. (2014) The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine. Dev Cell 31:690-706
Welsh, Ian C; Thomsen, Michael; Gludish, David W et al. (2013) Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell 26:629-44

Showing the most recent 10 out of 12 publications