There is a profound need for newly trained physician/scientists to enter academic careers in Neonatology. The Division of Neonatology at Rainbow Babies &Children's Hospital has, for several decades, trained fellowship graduates to assume leadership roles in Neonatology, both nationally and internationally, and is uniquely qualified to meet this challenge. In this proposal we seek to complement our existing scientific strengths in respiratory neurobiology, brain development and neurodevelopmental outcome with a focus on inflammation. This will enable trainees to address the broad spectrum of neonatal morbidities. We have assembled an accomplished M.D., and Ph.D. mentoring faculty with scientific expertise in these three thematic areas, encompassing both basic translational and patient oriented research. We will recruit trainees to a two year intensive research immersion under the mentorship of established investigators within one of these thematic areas and a mentorship committee which may include K-funded junior faculty preceptors to serve as trainee role models. As the primary mentor experience of the trainee is key, we have chosen mentoring faculty with a strong track record for physician/scientist training and will provide close monitoring of the trainee/mentorship relationship. Trainees will be exposed to a well structured didactic program designed to introduce them to """"""""team science"""""""", and provide all the necessary skills for academic career development. Optional curricular activities will be designed for the chosen field of basic science or epidemiologic research [e.g., award of a Masters of Science degree in Clinical Research]. Oversight will occur via both stringent internal Steering Committee review [meeting benchmarks, program retreat, etc.] and an External Review Committee comprised of highly regarded academic leaders in neonatology. Recruitment of competitive trainees to the program will particularly focus on minority candidates for which we have a strong track record. Trainees will have ample opportunity via existing Institutional NIH Career Development Awards to competitively transition from fellowship to faculty as basic translational or patient oriented researchers committed to improving neonatal health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD060537-02
Application #
7926918
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (MR))
Program Officer
Raju, Tonse N
Project Start
2009-09-03
Project End
2014-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
2
Fiscal Year
2010
Total Cost
$191,603
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Raffay, Thomas M; Dylag, Andrew M; Sattar, Abdus et al. (2018) Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age. Pediatr Res :
Di Fiore, Juliann M; Dylag, Andrew M; Honomichl, Ryan D et al. (2018) Early inspired oxygen and intermittent hypoxemic events in extremely premature infants are associated with asthma medication use at 2 years of age. J Perinatol :
Ford, Stephanie M; McPheeters, Matthew T; Wang, Yves T et al. (2017) Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease. Congenit Heart Dis 12:322-331
Dylag, Andrew M; Mayer, Catherine A; Raffay, Thomas M et al. (2017) Long-term effects of recurrent intermittent hypoxia and hyperoxia on respiratory system mechanics in neonatal mice. Pediatr Res 81:565-571
Reyburn, Brent; Di Fiore, Juliann M; Raffay, Thomas et al. (2016) The Effect of Continuous Positive Airway Pressure in a Mouse Model of Hyperoxic Neonatal Lung Injury. Neonatology 109:6-13
Harmon, Heidi M; Taylor, H Gerry; Minich, Nori et al. (2015) Early school outcomes for extremely preterm infants with transient neurological abnormalities. Dev Med Child Neurol 57:865-71
Raffay, Thomas; Kc, Prabha; Reynolds, James et al. (2014) Repeated ?2-adrenergic receptor agonist therapy attenuates the response to rescue bronchodilation in a hyperoxic newborn mouse model. Neonatology 106:126-32
Wang, Katherine; Difiore, Juliann M; Martin, Richard J et al. (2013) Markers for severity of illness associated with decreased snoring in toddlers born ELGA. Acta Paediatr 102:e39-43
Payne, Allison H; Hintz, Susan R; Hibbs, Anna Maria et al. (2013) Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA Pediatr 167:451-9