This program is dedicated to the training of cardiovascular scientists with MD and or PhD degrees. Over the past 10 years, the program was highly successful and focused on training in developmental biology, genetics, signal transduction, and vascular biology. To enable cardiovascular science to benefit from the ongoing biologic revolution, notably advanced by the Human Genome Project, the program proposes to enhance and broaden the scope of opportunities for our trainees. The program will enable trainees to gain new competencies in functional genomics, complex multigenic disorders, cardiovascular gene therapy, genomic pharmacology, molecular imaging, and myocardial cell biology. These increased opportunities for training have been gained by recruiting new faculty who are recognized leaders in these evolving fields, as well as proven, outstanding mentors. The program continues to be based in the Cardiovascular Research Center at the Massachusetts General Hospital with additional training sites at Harvard University, Massachusetts institute of Technology, and New England Medical Center. Training is focused on laboratory work under the supervision of skilled primary and secondary mentors. Course work is tailored to the needs of the trainee with additional didactic experiences serving to broaden the trainee's exposure to the forefront of cardiovascular science. The faculty and trainees are closely linked by a tradition of collaboration and a shared training mission. Importantly, an enhanced CVRC seminar series serves as an opportunity to bring all of the trainees together on a regular basis. Trainee progress is closely monitored by the mentors, the program director, and a Steering Committee, with additional advice provided by an External Advisory Committee. Graduates of this training program are prepared to lead independent research programs at the cutting edge of cardiovascular science for the next decades.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007208-28
Application #
6877777
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Scott, Jane
Project Start
1993-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
28
Fiscal Year
2005
Total Cost
$609,985
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Benson, Mark D; Yang, Qiong; Ngo, Debby et al. (2018) Genetic Architecture of the Cardiovascular Risk Proteome. Circulation 137:1158-1172
Hu, Ray; Morley, Michael P; Brandimarto, Jeffrey et al. (2018) Genetic Reduction in Left Ventricular Protein Kinase C-? and Adverse Ventricular Remodeling in Human Subjects. Circ Genom Precis Med 11:e001901
Jacob, Jaison; Ngo, Debby; Finkel, Nancy et al. (2018) Application of Large-Scale Aptamer-Based Proteomic Profiling to Planned Myocardial Infarctions. Circulation 137:1270-1277
Khera, Amit V; Chaffin, Mark; Aragam, Krishna G et al. (2018) Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet 50:1219-1224
Jordi, Josua; Guggiana-Nilo, Drago; Bolton, Andrew D et al. (2018) High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy. Sci Adv 4:eaav1966
Paffett-Lugassy, Noelle; Novikov, Natasha; Jeffrey, Spencer et al. (2017) Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field. Development 144:4616-4624
Tucker, Nathan R; McLellan, Micheal A; Hu, Dongjian et al. (2017) Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy. Circ Cardiovasc Genet 10:
Tucker, Nathan R; Dolmatova, Elena V; Lin, Honghuang et al. (2017) Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential. Circ Cardiovasc Genet 10:
Strauss, David G; Vicente, Jose; Johannesen, Lars et al. (2017) Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. Circulation 135:1300-1310
Hucker, William J; Hanley, Alan; Ellinor, Patrick T (2017) Improving Atrial Fibrillation Therapy: Is There a Gene for That? J Am Coll Cardiol 69:2088-2095

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