EXCEED THE SPACE PROVIDED. This renewal application requests continued support for the research training program in Hemostasis and Thrombosis at the University of Vermont. The focal point of the program is the basic and clinical research training of M.D. and Ph.D. fellows. It is our intent to maintain this highly integrated and symbiotic research environment and extend training opportunities to pregraduate and short-term students as well. Postdoctoral candidates with an M.D. degree typically enter the program following the first year of residency training. Candidates with a Ph.D. degree usually begin training immediately after fulfilling their degree requirements. Postdoctoral candidateswith more experience are also admitted. Predoctoral candidates will enter the program after completingthe first year of their graduate program. Short-term students from the MedicalCollege at the University of Vermont will participate in the research program during summer breaks and preference will be given to students who wish to return for several summers. All candidatesshare a desire to pursue research and further their knowledge in the fields of hemostasis and thrombosis. The heart of the training program is the research of the training faculty, all of whom have well established endeavors covering multiple basic and clinical aspects of hemostasis and thrombosis. The program faculty include the Chairs of the Departments of Biochemistry, Medicine, and Pathology, the Associate Dean of Research, and other distinguished faculty members. There is a high degree of cooperative interchange amongst the research laboratories of the faculty members of this program. The training faculty have complementaryresearch interests and a long history of close interactionon both research and educationalenterprises. Primary training of the fellows in this program occurs within the research laboratory environment and is supplemented with formal educational programs within the College of Medicine at the University of Vermont. Seminars, conferences, journal clubs, and laboratory meetings also contribute to the intellectual and social interactionof the faculty and fellows. This program provides trainees with a strong backgroundin basic research skills and allows trainees to join a vast network of collaborating investigators, including the current and former members of the participating laboratories. Trainees are thereforewell prepared for future research endeavors in any field. PERFORMANCE SITE ========================================Section End===========================================

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007594-20
Application #
6896792
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Mondoro, Traci
Project Start
1990-07-01
Project End
2006-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
20
Fiscal Year
2005
Total Cost
$224,442
Indirect Cost
Name
University of Vermont & St Agric College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Abbott, Jamie A; Meyer-Schuman, Rebecca; Lupo, Vincenzo et al. (2018) Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy. Hum Mutat 39:415-432
Ferris, Lauren A; Kelm Jr, Robert J (2018) Structural and functional analysis of single-nucleotide polymorphic variants of purine-rich element-binding protein B. J Cell Biochem :
O'Keefe, John P; Dustin, Christopher M; Barber, Drew et al. (2018) A ""Seleno Effect"" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase. Biochemistry 57:1767-1778
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Sheehe, Jessica L; Bonev, Adrian D; Schmoker, Anna M et al. (2018) Oxidation of cysteine 117 stimulates constitutive activation of the type I? cGMP-dependent protein kinase. J Biol Chem 293:16791-16802
Abbott, Jamie A; Livingston, Nathan M; Egri, Shawn B et al. (2017) Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry. Methods 113:64-71
Landry, K K; Alexander, K S; Zakai, N A et al. (2017) Association of stroke risk biomarkers with stroke symptoms: the Reasons for Geographic and Racial Differences in Stroke cohort. J Thromb Haemost 15:21-27
Abbott, Jamie A; Guth, Ethan; Kim, Cindy et al. (2017) The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. Biochemistry 56:3619-3631
Longden, Thomas A; Dabertrand, Fabrice; Koide, Masayo et al. (2017) Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci 20:717-726

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