An expectation of training in research today is interdisciplinary teams and technology to solve complex biological problems of which cardiovascular (CVD) is a prototypical example. Coupled with diminishing research budget allocations there is a significant need to reform training programs. In this period of challenge, there is an unprecedented need to address multiple areas of deficiency including (a) core technology proficiency (b) mentorship (c) recruitment and retention of trainees including minority applicants and (d) specialized training paths for physician-scientists. In this renewal application of the Vascular Biology Training Program, two existing T32 programs (The Vascular Biology Training Program and the Training Program in Cardiac Vascular and Cell Biology) at the University of Maryland School of Medicine (UMSOM) have been merged to create the Interdisciplinary Training Program in Cardiovascular Disease (ITCVD-T32) that will educate an elite cohort of five predoctoral and 5 post-doctoral trainees. The program will emphasize research training in five key areas that are nationally recognized at UMSOM including Inflammation and Immunological Mechanisms of Cardiovascular Disease; Hypertension and Vascular Pathophysiology; Heart Function, Failure and Arrythmias, Cardiac Repair and Regeneration and Genetics and Genomics of Cardiovascular Disease. The ITCVD-T32 will be governed by the T32 steering committee which comprises 2 highly accomplished co- directors (a translational/basic scientist and physician/scientist) with strong NIH funded programs with additional oversight by external and internal advisory committees. Our pre-doctoral and post-doctoral trainees can pick from 39 outstanding and well-funded mentors (with over $22 million in direct costs of grant support) representing 9 basic science and clinical departments within the University of Maryland School of Medicine and University of Maryland College Park. The faculty includes those located within the Center for Vascular and Inflammatory Diseases (CVID), Center for Biomedical Engineering and Technology, the Program for Personalized and Genomic Medicine, as well as members of the Department of Physiology and the Division of Cardiovascular Medicine within the Department of Medicine. The juxtaposition of resources with a cross- disciplinary mesh of investigators will provide unparalleled opportunities for training th next generation of CVD investigators.

Public Health Relevance

Cardiovascular disease is the leading cause of morbidity and mortality in the US and worldwide, and there is a significant need for training a new generation of investigators in next-generation technologies to solve this complex disease (CVD). This Training Program will equip an elite group of pre-doctoral and post-doctoral scholars to become the next-generation of scientists and physician scientists capable of advancing our understanding of Cardiovascular Disease thereby accelerating the discovery of cures for this Disease

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland Baltimore
Schools of Medicine
United States
Zip Code
Wehman, Brody; Mazzeffi, Michael; Chow, Robert et al. (2018) Thoracoscopic Sympathectomy for Refractory Electrical Storm After Coronary Artery Bypass Grafting. Ann Thorac Surg 105:e99-e101
French, Beth M; Sendil, Selin; Sepuru, Krishna Mohan et al. (2018) Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models. Xenotransplantation 25:e12385
Fondrie, William E; Liang, Tao; Oyler, Benjamin L et al. (2018) Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids. Sci Rep 8:15857
O'Neill, Natalie A; Zhang, Tianshu; Braileanu, Gheorghe et al. (2018) Pilot Study of Delayed ICOS/ICOS-L Blockade With ?CD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model. Transplant Direct 4:e344
Liu, Yewei; Russell, Sarah J; Schneider, Martin F (2018) Foxo1 nucleo-cytoplasmic distribution and unidirectional nuclear influx are the same in nuclei in a single skeletal muscle fiber but vary between fibers. Am J Physiol Cell Physiol 314:C334-C348
Landers-Ramos, Rian Q; Prior, Steven J (2018) The Microvasculature and Skeletal Muscle Health in Aging. Exerc Sport Sci Rev 46:172-179
Landers-Ramos, Rian Q; Sapp, Ryan M; VandeWater, Emily et al. (2017) Investigating the extremes of the continuum of paracrine functions in CD34-/CD31+ CACs across diverse populations. Am J Physiol Heart Circ Physiol 312:H162-H172
Leung, Lisa M; Fondrie, William E; Doi, Yohei et al. (2017) Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids. Sci Rep 7:6403
Li, Lushen; Baxter, Shaneen S; Gu, Ning et al. (2017) Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci 130:1475-1485
Matyas, Jessica J; O'Driscoll, Cliona M; Yu, Laina et al. (2017) Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury. J Neurosci 37:3956-3971

Showing the most recent 10 out of 74 publications