This T32 renewal application for years 27-31 seeks continuing support for this exemplary Lung Biology and Pathobiology Training Program at The University of Illinois College of Medicine, Chicago. Our primary emphasis continues to be in the training of the next generation of creative and meritorious lung researchers at the predoctoral and postdoctoral levels. To support our goal of training in this rapidly-evolving and competitive scientific environment, we have re-vitalized the program to encompass development of careers of individuals seeking to become independent investigators as well as aspiring to research-related careers. The Program continues to have a strong focus on fostering career development and promoting essential skills such as in problem-solving skills and developing characteristics such as resilience and grit which are necessary for long- term success in any research-intensive career. Our alumni move on to successful careers in academia, industry, and related-fields. In addition to the cohort of stellar well-funded preceptors we have always had, we have selectively replenished our faculty to provide to new training opportunities. Our Training Program covers five complementary thematic areas: (1) Biology and Pathobiology of the Lung Vasculature, (2) Regenerative Mechanisms in Lung and Vascular Biology, (3) Cellular and Humoral Basis of Lung Inflammation and Injury, (4) Cell Signaling in Lung Injury, and (5) Lung and Vascular Genomics. The Program's vitality is reflected in the numbers of highly qualified applicants applying and those we must decline. We anticipate an even greater interest with the launch of new thematic areas, recruitment of exceptional faculty, and programs such as the internally funded internship program and summer undergraduate research program to attract better trainees. Therefore, we are requesting 7 predoctoral (as opposed to 6 PhD trainees currently) while maintaining 6 postdoctoral training positions. The Program is designed to provide mentoring by a primary preceptor, however co-mentorship is encouraged. Trainees formulate Individual Development Plans with their mentor(s) and their progress is carefully monitored throughout based on various systems and checks and balances in place. Thus, we are poised with renewed vigor to train a select group of individuals in lung-related research and important intersecting disciplines for careers in academia, research institutions, biopharmaceutical industry, and other burgeoning areas.

Public Health Relevance

This training grant application focused on lung biology and pathobiology requests continuing support for 7 predoctoral and 6 postdoctoral trainees. The Training Program is grounded in 5 inter-related thematic areas of research training: (1) Biology and Pathobiology of Lung Vasculature, (2) Regenerative Mechanisms in Lung and Vascular Biology, (3) Cellular and Humoral Bases of Lung Inflammation and Injury, (4) Cell Signaling Mechanisms in Lung Injury, and (5) Lung and Vascular Genomics. We are well positioned to continue to train a highly-qualitied group of young scientists, providing a range of skills needed in a rapidly-evolving and increasingly competitive scientific environment that can be applied in careers in both academic research and alternative pathways.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Kalantari, Roya
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois at Chicago
Schools of Medicine
United States
Zip Code
Di, Anke; Xiong, Shiqin; Ye, Zhiming et al. (2018) The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation. Immunity 49:56-65.e4
Le Master, Elizabeth; Huang, Ru-Ting; Zhang, Chongxu et al. (2018) Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins. Arterioscler Thromb Vasc Biol 38:64-75
Baruah, Jugajyoti; Hitzman, Ryan; Zhang, Jane et al. (2017) The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model. J Biol Chem 292:20785-20798
Tsang, Kit Man; Hyun, James S; Cheng, Kwong Tai et al. (2017) Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1?. Stem Cell Reports 9:796-806
Wary, Anita; Wary, Neil; Baruah, Jugajyoti et al. (2017) Chromatin-modifying agents convert fibroblasts to OCT4+ and VEGFR-2+ capillary tube-forming cells. PLoS One 12:e0176496
Yamada, Kaori H; Kang, Hojin; Malik, Asrar B (2017) Antiangiogenic Therapeutic Potential of Peptides Derived from the Molecular Motor KIF13B that Transports VEGFR2 to Plasmalemma in Endothelial Cells. Am J Pathol 187:214-224
Rexius-Hall, Megan L; Rehman, Jalees; Eddington, David T (2017) A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1? and HIF-2?. Integr Biol (Camb) 9:742-750
Zhang, Lianghui; Jambusaria, Ankit; Hong, Zhigang et al. (2017) SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+Progenitor Cells. Circulation 135:2505-2523
Yazbeck, Pascal; Tauseef, Mohammad; Kruse, Kevin et al. (2017) STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry. Sci Rep 7:42758
Gong, Haixia; Liu, Menglin; Klomp, Jeff et al. (2017) Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Sci Rep 7:42127

Showing the most recent 10 out of 79 publications