The purpose of this program is to provide rigorous multidisciplinary research training for physician-scientists committed to careers in academic medicine and for PhD postdoctoral fellows in cardiovascular biology and medicine. Our training program incorporates two guiding principles: 1) biomedical research requires teams of investigators with diverse scientific and medical backgrounds possessing complementary expertise and perspective, and 2) there are no shortcuts to a career in cardiovascular research; rigorous didactic training, structured mentorship, a focused research project, and constructive feedback are required. The program is centered in the University of Pennsylvania Cardiovascular Institute (CVI), which includes 190 members in 16 departments performing a broad spectrum of cardiovascular science. Considerable infrastructure support from the School of Medicine is committed to the program, including integrated basic and translational research space and core laboratories in the Smilow Center for Translational Research. This renewal application will support 7 MD, MD/PhD, and PhD postdoctoral fellows per year performing 2-3 years of dedicated research training. Thirty-four NIH-funded Penn CVI faculty members in the Departments of Medicine, Surgery, Cell and Developmental Biology, Genetics, Physiology, Systems Pharmacology and Therapeutics, and Bioengineering, serve as trainers and mentors. Three tracks have been created. The Basic Track prepares trainees for careers in cardiovascular science using laboratory approaches. The Clinical and Translational Track prepares trainees for research careers at the interface of laboratory science and clinical investigation, including deep-phenotyping in human subjects, applied genomics, novel devices, and therapeutics. A new track in Outcomes and Health Services Research prepares trainees for careers that leverage big data to improve health care delivery and outcomes. The core of our curriculum is a supervised research preceptorship. Practical research training is supplemented by graduate and medical school classwork, lectures, seminars, skill classes (medical writing, obtaining extramural support), postdoctoral career advising and courses in the ethical conduct of research. A successful strategy to attract individuals from under-represented minorities will be maintained. Internal and External Advisory Committees review trainee progress and programmatic direction. Over the past 15 years metrics of the training program's success include: 1) recruitment of outstanding MD, MD/PhD and PhD trainees, 2) > 95% of trainees completing the program (several having obtained advanced degrees), 3) an average of 6.2 manuscripts published per trainee (many in high-impact journals), 4) a vast majority of trainees obtaining academic positions or pursuing additional postdoctoral studies. Programmatic enhancements described in this application include the new track in Outcomes and Health Services Research and enhanced ties to the Leonard Davis Institute of Health Economics, Penn's CTSA, and the department of Bioengineering.

Public Health Relevance

There is an acute shortage of well-trained MD and PhD investigators performing high impact cardiovascular research to combat the burden of cardiovascular disease. The University of Pennsylvania Cardiovascular Institute's training program in cardiovascular biology and medicine is uniquely positioned to prepare MD and PhD postdoctoral trainees for successful careers in cardiovascular science. Our aim is to arm the next generation of cardiovascular scientists with the latest tools to improve cardiovascular health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007843-22
Application #
9413275
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1996-09-15
Project End
2022-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
22
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Chadwick, Alexandra C; Evitt, Niklaus H; Lv, Wenjian et al. (2018) Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3. Circulation 137:975-977
Rossidis, Avery C; Stratigis, John D; Chadwick, Alexandra C et al. (2018) In utero CRISPR-mediated therapeutic editing of metabolic genes. Nat Med 24:1513-1518
Zacharias, William J; Frank, David B; Zepp, Jarod A et al. (2018) Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555:251-255
Chadwick, Alexandra C; Musunuru, Kiran (2018) CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia. Arterioscler Thromb Vasc Biol 38:12-18
Zamani, Payman; Tan, Victor; Soto-Calderon, Haideliza et al. (2017) Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circ Res 120:1151-1161
Kalra, Ankur; Adusumalli, Srinath; Sinha, Shashank S (2017) Cultivating Skills for Success in Learning Health Systems: Learning to Lead. J Am Coll Cardiol 70:2450-2454
Chadwick, Alexandra C; Wang, Xiao; Musunuru, Kiran (2017) In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing. Arterioscler Thromb Vasc Biol 37:1741-1747
Adusumalli, Srinath; Mazurek, Jeremy A (2017) Pulmonary Hypertension Due to Left Ventricular Cardiomyopathy: Is it the Result or Cause of Disease Progression? Curr Heart Fail Rep 14:507-513
Yeh, Yi-Cheun; Corbin, Elise A; Caliari, Steven R et al. (2017) Mechanically dynamic PDMS substrates to investigate changing cell environments. Biomaterials 145:23-32
Pajcini, Kostandin V; Xu, Lanwei; Shao, Lijian et al. (2017) MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Sci Signal 10:

Showing the most recent 10 out of 91 publications