Pediatric cardiology remains a field with relatively few researchers, basic or clinical. The reasons for this are complex and may relate to trends affecting many pediatric subspecialities. Nevertheless, the Children's Hospital of Philadelphia (CHOP) cardiology research programs overall have continued to demonstrate outstanding growth, offering a broad array of research training opportunities for the postdoctoral fellows in this Program. We seek to train physicians and basic scientists in molecular therapeutics for heart disease in children. It is our expectation that our trainees will become creative cutting edge researchers whose efforts will lead to new therapies and diagnostic techniques for pediatric cardiology. Our working definition of molecular therapy has now been broadened to enable this goal and includes training opportunities in four major areas: I) Experimental pharmacology and gene therapy; II) Molecular genetics and development; III) Cardiovascular pathophysiology, IV) Imaging, outcomes, clinical pharmacology, and clinical epidemiology. There has been enthusiastic interest in this T32 program from its inception including a strong minority recruitment. An outstanding cohort of productive trainees has already graduated from our Program. The composition of our proposed trainee group for the Program renewal is planned to include 4 physicians, who will be recruited from our pediatric cardiology fellowship, and 3 Ph.D. scientists or non-pediatric cardiology physician scientists. We have increased by one the number of physicians because of the increase in interest among our cardiology fellows at CHOP.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Commarato, Michael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital of Philadelphia
United States
Zip Code
Battig, Mark R; Fishbein, Ilia; Levy, Robert J et al. (2018) Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Deliv Transl Res 8:954-963
Geanacopoulos, Alexandra T; Savla, Jill J; Pogoriler, Jennifer et al. (2018) Bronchoscopic and histologic findings during lymphatic intervention for plastic bronchitis. Pediatr Pulmonol 53:1574-1581
DiLorenzo, Michael; Hwang, Wei-Ting; Goldmuntz, Elizabeth et al. (2018) Diastolic dysfunction in tetralogy of Fallot: Comparison of echocardiography with catheterization. Echocardiography 35:1641-1648
Mercer-Rosa, Laura; Zhang, Xuemei; Tanel, Ronn E et al. (2018) Perioperative Factors Influence the Long-Term Outcomes of Children and Adolescents with Repaired Tetralogy of Fallot. Pediatr Cardiol :
Chang, J C; Knight, A M; Xiao, R et al. (2018) Use of echocardiography at diagnosis and detection of acute cardiac disease in youth with systemic lupus erythematosus. Lupus 27:1348-1357
O'Byrne, Michael L; McBride, Michael G; Paridon, Stephen et al. (2018) Association of Habitual Activity and Body Mass Index in Survivors of Congenital Heart Surgery: A Study of Children and Adolescents With Tetralogy of Fallot, Transposition of the Great Arteries, and Fontan Palliation. World J Pediatr Congenit Heart Surg 9:177-184
Avitabile, Catherine M; Goldberg, David J; Leonard, Mary B et al. (2018) Leg lean mass correlates with exercise systemic output in young Fontan patients. Heart 104:680-684
Zacharias, William J; Frank, David B; Zepp, Jarod A et al. (2018) Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555:251-255
DiLorenzo, Michael P; Elci, Okan U; Wang, Yan et al. (2018) Longitudinal Changes in Right Ventricular Function in Tetralogy of Fallot in the Initial Years after Surgical Repair. J Am Soc Echocardiogr 31:816-821
Mohan, Shaun; Nandi, Deipanjan; Stephens, Paul et al. (2018) Implementation of a Clinical Pathway for Chest Pain in a Pediatric Emergency Department. Pediatr Emerg Care 34:778-782

Showing the most recent 10 out of 145 publications