EXCEED THE SPACE PROVIDED. The two major research directions for the Division of Hematology at Stanford are malignant hematology and vascular biology. This involvesboth basic and clinical research. The.program described herein will train postdoctoral fellows for a career in academic hematology. Candidates with MD or MD/PnD degrees who have completed training in Internal Medicine will be admitted to the three-year program. The first year of the program consists of an intensive training in clinical hematology,including benign and malignant hematology, stem cell and bone marrow transplantation, and transfusion medicine. In Year 2 and Year 3, the trainees will devote the majority of their time to research-based study. This will be done in a Basic-Scientist Pathway or a Clinical Investigator Pathway. The Basic Scientist Pathwayis primarily for trainees with substantialprior basic research experience, focusing on malignanthematology,vascularbiology and related basic research areas, The Clinical Investigator Pathway provides formal training in clinical research and incorporates the K30 Clinical Investigator Training program at Stanford under the direction of Dr. Mark Hlatky, leading to a Master's degree at the completion of formal training. In addition to the didactictraining, the Clinical Investigator Pathway fellow will also conduct hands-on clinical trials in the Division of Hematology. Fellow stipend support for the research training in Year 2 and Year 3 is requested in this grant application.More than three years of trainingis often required. Trainees are encouraged to apply for and obtain their own independentmentored research training support (K08 or K23) in Year 4. For each fellow, the research training will be supervised by a full-time faculty member in the Division of Hematology, or one of a numberof associate faculty members at Stanford University, representing disciplines relevant to hematology training. These include faculty in biochemistry, molecular pharmacology, microbiology, immunology, pathology, medical oncology, bone marrow transplantation, cardiology, pediatrics, epidemiology, outcome research and health policy. The progress of each fellow will be reviewed by the Program Director and the Training Program Steering Committee. At the conclusion of their training,trainees will be prepared for a career in academic hematology, as an independentinvestigator at the forefront of science and hematology. 'ERFORMANCE SITE(S) (organization, city, state) Stanford University School of Medicine, Palo Alto Veterans' Affairs Health Care System, Lucille Packard Children's Hospital KEY PERSONNEL ========================================Section End===========================================
