This proposal describes a unique multidisciplinary physician-scientist training program that will be created at Baylor College of Medicine. It will be a school-wide program that is open to all clinical and basic science departments. It represents an effort at Baylor to reverse the national trend in the decline in the number of physicians who are going into academic research-oriented careers. In the last quarter of a century, a declining number of physician-scientists pursing avenues of biomedical research was noted first by James B. Wyngaarden 1977, and subsequently, repeatedly, by other leaders in biomedicine and, recently, by members of congress. We at Baylor have established a pilot program to support physicians from any of the clinical departments to undergo rigorous research training in NIH-funded basic science laboratories. We are seeking support for the Program that has been named the Molecular Medicine Scholars Physician-Scientist Training Program, and the trainees will be called Molecular Medicine Scholars. It is a multidisciplinary program that is open to physician-trainees from all clinical departments at Baylor who will train with mentors selected from nine Departments. The Program covers disease-oriented as well as fundamental research areas that are within the mission of the NHLBI. This exciting program represents a partnership between clinical and basic science departments with the clinical departments buying into the existing excellent basic research activities at Baylor and sharing expenses with the basic science departments, both sharing the common goal of training the next generation of molecular physician-scientists. We are hopeful that the Program will play a significant role in reversing the national trend of increasing numbers of well-trained physicians leaving an academic research oriented career in biomedicine.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
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Baylor College of Medicine
Internal Medicine/Medicine
Schools of Medicine
United States
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Yang, Yisheng; Bush, Sean P; Wen, Xianjie et al. (2017) Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic ? Cell Differentiation and Function. Endocrinology 158:9-20
Yang, Yisheng; Chan, Lawrence (2016) Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev 37:190-222
Buras, Eric Dale; Yang, Lina; Saha, Pradip et al. (2015) Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J 29:3537-48
Thacker, Stephen; Moran, Ana; Lionakis, Mihalis et al. (2014) Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock. J Infect 68:231-41
Kojima, Hideto; Kim, Jongoh; Chan, Lawrence (2014) Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Trends Endocrinol Metab 25:178-87
Wiszniewski, Wojciech; Hunter, Jill V; Hanchard, Neil A et al. (2013) TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. Am J Hum Genet 93:197-210
Maiellaro-Rafferty, K; Wansapura, J P; Mendsaikhan, U et al. (2013) Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy. J Mol Cell Cardiol 60:151-60
Gutierrez, Absalon D; Balasubramanyam, Ashok (2012) Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management. Endocrine 41:1-10
Gutierrez, Absalon D; Sathyanarayana, Padma; Konduru, Somasekhar et al. (2012) The effect of pioglitazone treatment on 15-epi-lipoxin A4 levels in patients with type 2 diabetes. Atherosclerosis 223:204-8
Jeyaraj, Darwin; Haldar, Saptarsi M; Wan, Xiaoping et al. (2012) Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 483:96-9

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