The purpose of this training program is to prepare physicians and bio-medical scientists for academic careers in cardiovascular research. The theme that permeates this program is that students must be offered both a breadth of exposure and a depth of expertise to acquire the essential aptitude and tools to thrive in an aggressive academic environment. Each of the 24 training faculty has on-going federal and other research funding, collectively totaling $22 million direct cost dollars annually. They come from four colleges, two centers, ten departments and the Gill Heart Institute. One of the distinctive strengths of our instructional team, and therefore of this program, is that these individuals have a long and well-documented history of collaboration in graduate-training and in the development and maintenance of supplemental training opportunities. Trainees will be recruited from the Integrated Biomedical Sciences program and from other participating academic units. A curriculum that emphasizes cross-fertilization between the clinical and basic sciences will be provided. Members of our faculty have an established history of recruiting and training minority students, and particular attention will be given to continuing this commitment. The didactic experience will include formal course work, including an opportunity to enroll in a closely mentored scientific writing class, and mentored participation in weekly journal clubs, topical seminar series and Gill Heart Institute programs. Research training is the backbone of this program. Trainees will choose from four areas of research that seek to elucidate the mechanisms of arrhythmogenesis, BP regulation/hypertension endothelial function/atherosclerosis and ischemic heart disease/cardiac myocyte dysfunction. The proposed program provides a setting that will increase the effectiveness and efficiency of our on-going multi-disciplinary approach to graduate education in the cardiovascular sciences.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL072743-04
Application #
7204131
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Commarato, Michael
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
4
Fiscal Year
2007
Total Cost
$126,002
Indirect Cost
Name
University of Kentucky
Department
Physiology
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Wehner, Gregory J; Jing, Linyuan; Haggerty, Christopher M et al. (2018) Comparison of left ventricular strains and torsion derived from feature tracking and DENSE CMR. J Cardiovasc Magn Reson 20:63
Parker, Matthew W; Vander Kooi, Craig W (2017) Plate-Based Assay for Measuring Direct Semaphorin-Neuropilin Interactions. Methods Mol Biol 1493:73-87
Dong, Anping; Mueller, Paul; Yang, Fanmuyi et al. (2017) Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice. Thromb Res 159:58-64
Levitan, Bryana M; Manning, Janet R; Withers, Catherine N et al. (2016) Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart. J Cardiovasc Transl Res 9:432-444
Parker, Matthew W; Linkugel, Andrew D; Goel, Hira Lal et al. (2015) Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form. Structure 23:677-87
Mueller, Paul; Ye, Shaojing; Morris, Andrew et al. (2015) Lysophospholipid mediators in the vasculature. Exp Cell Res 333:190-4
Wehner, Gregory J; Suever, Jonathan D; Haggerty, Christopher M et al. (2015) Validation of in vivo 2D displacements from spiral cine DENSE at 3T. J Cardiovasc Magn Reson 17:5
Wehner, Gregory J; Grabau, Jonathan D; Suever, Jonathan D et al. (2015) 2D cine DENSE with low encoding frequencies accurately quantifies cardiac mechanics with improved image characteristics. J Cardiovasc Magn Reson 17:93
Manning, Janet R; Withers, Catherine N; Levitan, Bryana et al. (2015) Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging. Am J Physiol Heart Circ Physiol 309:H1336-45
Parker, Matthew W; Vander Kooi, Craig W (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. Anal Biochem 453:4-6

Showing the most recent 10 out of 48 publications