The proposed program of training in cardiovascular surgery research is multidisciplinary in that NIH funded cardiothoracic surgeons, cardiologists, epidemiologists and basic scientists will make up the faculty. Faculty were recruited from not only Beth Israel Deaconess Medical Center, but also from the other Harvard Hospitals, Harvard Medical School, Harvard School of Public Health and other Affiliated Institutions. The faculty were chosen in large part based on their prior record of training research fellows and their reputation as academic physicians and scientists. Opportunities are available for basic and clinical research in the areas of vascular physiology and molecular biology, cardiac physiology and molecular and cellular biology, transplantation immunology, tissue engineering, cardiac pathology, and clinical outcomes research. The program is administered by the Program Director (Dr Sellke) and the Steering Committee and is carried on in close relationship to active clinical services. In addition, formal and informal course work and seminars are made available, depending on the research fellow needs. Trainees (4 each year) are appointed for a 2 year term beginning after the third year of surgical training. Trainees are assigned to one of many active laboratories directed by the faculty. Trainees select the laboratory and mentor of choice for their laboratory training, with advice from and ongoing monitoring of progress by the Program Director and faculty. Following completion of their research training, fellows will complete their surgical residency, and then be expected to complete a residency in cardiothoracic surgery. It is anticipated that this program in cardiovascular surgery research training will help the specialty continue to train outstanding academic surgeons in times of financial, clinical, and educational uncertainty.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076130-02
Application #
6876567
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Scott, Jane
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$219,661
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Sabe, Ashraf A; Elmadhun, Nassrene Y; Dalal, Rahul S et al. (2014) Resveratrol regulates autophagy signaling in chronically ischemic myocardium. J Thorac Cardiovasc Surg 147:792-8; Discussion 798-9
Lassaletta, Antonio D; Elmadhun, Nassrene Y; Burgess, Thomas A et al. (2014) Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia. Circ J 78:743-51
Lee, Lawrence S; Ghanta, Ravi K; Mokashi, Suyog A et al. (2013) Optimized ventricular restraint therapy: adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy. J Thorac Cardiovasc Surg 145:824-31
Feng, Jun; Liu, Yuhong; Dobrilovic, Nikola et al. (2013) Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus. Circulation 128:S144-51
Robich, Michael P; Chu, Louis M; Burgess, Thomas A et al. (2012) Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome. J Am Coll Surg 215:681-9
Lassaletta, Antonio D; Chu, Louis M; Elmadhun, Nassrene Y et al. (2012) Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction. J Surg Res 178:586-92
Chu, Louis M; Lassaletta, Antonio D; Robich, Michael P et al. (2012) Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine. Circulation 126:S65-72
Robich, Michael P; Chu, Louis M; Burgess, Thomas A et al. (2011) Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on myocardial function and perfusion. J Cardiovasc Pharmacol 57:122-30
Feng, Jun; Liu, Yuhong; Singh, Arun K et al. (2011) Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardiopulmonary bypass. Surgery 150:263-71
Chu, Louis M; Robich, Michael P; Lassaletta, Antonio et al. (2011) Hypercholesterolemia and chronic ischemia alter myocardial responses to selective cyclooxygenase-2 inhibition. J Thorac Cardiovasc Surg 142:675-81

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