This continuation proposal seeks funds for a training program in translational research applied to cardiovascular disease. The program recruits PhD and MD trainees through the Division of Cardiovascular Medicine at Oregon Health &Science University and the Heart Research Center. Six post-doctoral fellows per year are offered funding for two years of research training. The program offers exciting opportunities for bench to bedside training in one of three established groups that specialize in 1) obesity/diabetes, 2) developmental programming, and 3) regulatory processes. The 28 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training includes molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, bioengineering vascular elements, mathematical models of cardiovascular dysregulation. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. All trainees participate in Responsible Conduct of Research training and team science methods. This program is unique at OHSU in that mentoring is carried out in a team approach and because this training program is specifically designed to translate basic research into clinical benefit. A basic scientist and a clinical scientist plus on additional scientist serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. The scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity.

Public Health Relevance

This proposed program will address the urgent need for cardiovascular scientists who are trained broadly in translational sciences focused on cardiovascular disease. The program will train 30 scientists who will join the ranks of academia and promote cutting edge research in heart disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHL1)
Program Officer
Carlson, Drew E
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Oregon Health and Science University
Internal Medicine/Medicine
Schools of Medicine
United States
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Miranda, Cristobal L; Johnson, Lance A; de Montgolfier, Oriane et al. (2018) Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice. Sci Rep 8:613
Denfeld, Quin E; Winters-Stone, Kerri; Mudd, James O et al. (2018) Identifying a Relationship Between Physical Frailty and Heart Failure Symptoms. J Cardiovasc Nurs 33:E1-E7
Atkinson, Tamara; Packwood, William; Xie, Aris et al. (2018) Assessment of Novel Antioxidant Therapy in Atherosclerosis by Contrast Ultrasound Molecular Imaging. J Am Soc Echocardiogr 31:1252-1259.e1
Bading-Taika, Bayissi; Akinyeke, Tunde; Magana, Armando Alcazar et al. (2018) Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice. J Food Bioact 3:111-123
Denfeld, Quin E; Habecker, Beth A; Woodward, William R (2018) Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method development for a translational research study. BMC Res Notes 11:248
Wu, Melinda D; Atkinson, Tamara M; Lindner, Jonathan R (2017) Platelets and von Willebrand factor in atherogenesis. Blood 129:1415-1419
Denfeld, Quin E; Winters-Stone, Kerri; Mudd, James O et al. (2017) The prevalence of frailty in heart failure: A systematic review and meta-analysis. Int J Cardiol 236:283-289
Nelson, Jonathan W; Sklenar, Jiri; Barnes, Anthony P et al. (2017) The START App: a web-based RNAseq analysis and visualization resource. Bioinformatics 33:447-449
Denfeld, Quin E; Winters-Stone, Kerri; Mudd, James O et al. (2017) Frequency of and Significance of Physical Frailty in Patients With Heart Failure. Am J Cardiol 119:1243-1249
Vatankhah, Nasibeh; Jahangiri, Younes; Landry, Gregory J et al. (2017) Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing. J Vasc Surg 65:478-483

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