This T32 grant application submitted to NHLBI is a new application to support post-doctoral research training in the science of obesity and cardiovascular disease (CVD) at the University of Colorado Anschutz Medical Campus (UCAMC) and related institutions including the Barbara Davis Center for Childhood Diabetes, University of Colorado at Boulder (UCB), Denver Health, the Denver Veterans Administration Medical Center (VAMC), and the National Jewish Health (NJH). The intent of the training program is novel, broad-based and comprehensive including basic, clinical, and population science opportunities on how obesity relates to CVD. Areas of focused training will include hypertension, diabetes, obstructive sleep apnea and asthma, congestive heart failure (CHF), coronary heart disease (CHD), cerebrovascular disease, and sudden death. Training will also be focused on treatment and prevention of obesity. During the first year 2 slots are requested, and by the 3rd year a total of 4 slots divided between the two years of training are requested. An option for a third year will be the responsibility of the trainee's mentor. Although the emphasis will be placed on physician scientists, approximately 1 of the 4 slots will be used for a PhD fellow with a specific emphasis on translational research related to obesity and CVD. The UCAMC has invested over 2.5 million dollars into a new obesity institute (Colorado Obesity Research institute, CORI) that encompasses more than 100 faculty. Of these, 33 have been identified as preceptors/mentors and include senior and mid-career investigators many of whom are nationally and internationally recognized leaders in obesity and CVD science. To our knowledge there is no other program in the USA that has this focus, and in the current environment of the epidemic of obesity throughout the developed and developing world the need for targeted advanced training in how obesity relates to CVD is more than timely. The goal of recruiting, fostering and developing academic obesity/CVD translational scientists through this program will be completely dependent on this NHLBI training grant.

Public Health Relevance

This T32 grant application submitted to NHLBI is a new application to support post-doctoral research training in the science of obesity and cardiovascular disease (CVD) at the University of Colorado Anschutz Medical Campus and related institutions. The intent of the training program is novel, broad-based and comprehensive including basic, clinical, and population science opportunities on how obesity relates to CVD. To our knowledge there is no other program in the USA that has this focus, and in the current environment of the epidemic of obesity throughout the developed and developing world the need for targeted advanced training in how obesity relates to CVD is more than timely.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL116276-04
Application #
9293351
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Huang, Li-Shin
Project Start
2014-07-01
Project End
2019-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Rynders, Corey A; Schmidt, Stacy L; Bergouignan, Audrey et al. (2018) Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males. Physiol Rep 6:
Hawkins, Kellie L; Gordon, Kirsha S; Levin, Myron J et al. (2018) Herpes Zoster and Herpes Zoster Vaccine Rates Among Adults Living With and Without HIV in the Veterans Aging Cohort Study. J Acquir Immune Defic Syndr 79:527-533
Speaker, K J; Sayer, R D; Peters, J C et al. (2018) Effects of consuming a high-protein diet with or without soy protein during weight loss and maintenance: a non-inferiority, randomized clinical efficacy trial. Obes Sci Pract 4:357-366
Caldwell, Ann E; Masters, Kevin S; Peters, John C et al. (2018) Harnessing centred identity transformation to reduce executive function burden for maintenance of health behaviour change: the Maintain IT model. Health Psychol Rev 12:231-253
Melanson, Edward L; Swibas, Tracy; Kohrt, Wendy M et al. (2018) Validation of the doubly labeled water method using off-axis integrated cavity output spectroscopy and isotope ratio mass spectrometry. Am J Physiol Endocrinol Metab 314:E124-E130
Rynders, Corey A; Blanc, Stephane; DeJong, Nathan et al. (2018) Sedentary behaviour is a key determinant of metabolic inflexibility. J Physiol 596:1319-1330
Creasy, Seth A; Rynders, Corey A; Bergouignan, Audrey et al. (2018) Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring) 26:696-702
Sayer, R Drew; Dhillon, Jaapna; Tamer, Gregory G et al. (2017) Consuming Almonds vs. Isoenergetic Baked Food Does Not Differentially Influence Postprandial Appetite or Neural Reward Responses to Visual Food Stimuli. Nutrients 9:
Rynders, Corey A; Bergouignan, Audrey; Kealey, Elizabeth et al. (2017) Ability to adjust nocturnal fat oxidation in response to overfeeding predicts 5-year weight gain in adults. Obesity (Silver Spring) 25:873-880
Breathett, Khadijah; Willis, Shannon; Foraker, Randi E et al. (2017) Impact of Insurance Type on Initial Rejection Post Heart Transplant. Heart Lung Circ 26:164-171

Showing the most recent 10 out of 18 publications