Benign and malignant blood diseases cause major morbidity and mortality in the US and are rising in prevalence due to the rapid aging of the American population. Effective therapies are rare in part because of an insufficient number of physician-scientists and PhD scientists trained in Hematology research. This proposed Training Program will address this important problem by supporting the training of scientists in basic science or translational research in Hematology. We have designed a Training Program with rigorous research opportunities and close mentoring by faculty. We have assembled an outstanding panel of leading experts in Hematology as Program Faculty to direct fellows in their research endeavors. Fellows will enter the T32 Training Program after clinical training in adult Hematology or directly from the laboratories of Program Faculty through a competitive process. Physician-scientists interested in translational research will have the option of pursuing a Master's Degree in Clinical Epidemiology to acquire skills in the design of clinical trials. Fellow in the T32 Program will receive training in three broad areas of hematology research: hematopoiesis and stem cell biology;thrombosis and vascular biology;and immunology and immunotherapy. Research in the Training Program comprises two years and will be enhanced by didactic lectures, outstanding seminar series and a rich scientific environment. Successful implementation of this Training Program in Translational and Experimental Hematology will lead to new biological insights, novel means of prevention and new therapies for blood disorders by preparing future physician-scientist investigators for careers in research in Hematology.
The goal of this Training Program is to train future physician-scientists and PhD scientists with the rigorous research skills necessary to solve fundamental problems in Hematology. The Program will include training in both a a Basic Science Research Pathway and a Translational Research Pathway. Training will focus on three high priority areas in Hematology research, including: hematopoiesis and stem cell biology; thrombosis and vascular biology;and immunology and immunotherapy. The Training Program will prepare the fellows for successful, independent careers in research in Hematology and for new discoveries in understanding and treating blood diseases.
|Rosental, Benyamin; Kowarsky, Mark; Seita, Jun et al. (2018) Complex mammalian-like haematopoietic system found in a colonial chordate. Nature 564:425-429|
|Zhao, Lei; Yamaguchi, Yasuto; Ge, Xiaomei et al. (2018) Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients. Arthritis Res Ther 20:132|
|Barkal, Amira A; Weiskopf, Kipp; Kao, Kevin S et al. (2018) Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat Immunol 19:76-84|
|Ge, Xiaomei; Yamaguchi, Yasuto; Zhao, Lei et al. (2018) Prochemerin cleavage by factor XIa links coagulation and inflammation. Blood 131:353-364|
|Chao, Mark P; Gentles, Andrew J; Chatterjee, Susmita et al. (2017) Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Cell Stem Cell 20:329-344.e7|
|Rosental, Benyamin; Kozhekbaeva, Zhanna; Fernhoff, Nathaniel et al. (2017) Coral cell separation and isolation by fluorescence-activated cell sorting (FACS). BMC Cell Biol 18:30|
|Pavlov, Vadim; Rosental, Benyamin; Hansen, Nathaniel F et al. (2017) Hydraulic control of tuna fins: A role for the lymphatic system in vertebrate locomotion. Science 357:310-314|
|Chao, Mark P; Hong, Jison; Kunder, Christian et al. (2015) Refractory warm IgM-mediated autoimmune hemolytic anemia associated with Churg-Strauss syndrome responsive to eculizumab and rituximab. Am J Hematol 90:78-81|