The goal of this Cardiovascular Research Training Program (CRTP) is to provide outstanding training in basic cardiovascular research to promising predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 29 senior trainers and 8 junior trainers from 6 PhD programs and 4 clinical divisions at Case Western Reserve University. The recruited faculty are known for excellence in research, ample NIH funding, and robust research space. The Cardiovascular Research Institute (CVRI) serves as the integrating platform for all trainers on this grant. Training focuses on relating the basic approaches of molecular and cellular biology, physiology, biophysics, biomedical engineering, and imaging to mechanistic questions and problems pertinent to the cardiovascular system in health and disease, with particular emphasis on (a) Cardiovascular metabolism and inflammation, (b) Cardiac function, failure, and arrhythmia, (c) Vascular pathophysiology, and (d) Cardiovascular tissue engineering and imaging. The majority of student recruitment is through the Medical Scientist and Biomedical Sciences Training Programs, and includes a strong commitment to the recruitment of women and under-represented minorities. Predoctoral training is accomplished in PhD programs in Biomedical Engineering, Epidemiology & Biostatistics, Molecular Medicine, Pharmacology, Pathology, and Physiology & Biophysics. The basic coursework and guided training in research skills provided by these departmental programs is supplemented and enhanced by CRTP-specific components. These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in a weekly seminar series, a monthly journal club, and an annual CVRI research retreat. A CRTP faculty committee that includes senior trainers and junior trainers, who are developing independent programs in cutting-edge areas of cardiovascular research, mentor each trainee. Postdoctoral trainees, including physicians from the Harrington Physician Scientist Pathway, are appointed via their recruitment to CRTP trainer labs and will also participate in the Cardiovascular Healthcare Immersion, CVRI seminars/retreats/journal club, and the mentoring process. In total, this application seeks 8 positions (4 predoctoral and 4 postdoctoral) per year.
This Training Program is unique in offering discipline-based training in cardiovascular research within the context of a larger community of trainers from different disciplines who interact via the multiple programs and venues of the Case Cardiovascular Research Institute. Thus, all trainees are exposed to the diverse perspectives and investigational approaches that are critical to current cardiovascular research.
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| Sweet, David R; Fan, Liyan; Hsieh, Paishiun N et al. (2018) Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential. Front Cardiovasc Med 5:6 |
| Fan, Liyan; Hsieh, Paishiun N; Sweet, David R et al. (2018) Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity. Pharmacol Res 130:123-126 |
| Hsieh, Paishiun N; Sweet, David R; Fan, Liyan et al. (2017) Aging and the Krüppel-like factors. Trends Cell Mol Biol 12:1-15 |
