This program aims to provide excellent pre- and postdoctoral trainees with the breadth of knowledge and research skills essential to develop successful independent research programs in neuroendocrinology. Funds are requested for three pre- and two postdoctoral students. A hallmark of this program is that it unites trainees and faculty from two graduate programs to provide a perspective far broader than what could be obtained through a single program. The proposed training embraces multiple levels of analysis, from behavioral, to physiological, to cellular, to molecular. Predoctoral trainees enter the program in their third year, after finishing the specific course requirements of their respective graduate programs. Each student chooses both a primary advisor and a co-advisor. The role of the primary advisor is similar to the traditional role of the thesis advisor. The co-advisor ensures the multidisciplinary character of the training. Trainees will spend part of their time in the laboratory of the co-advisor, using techniques and approaches not available in their home laboratory to address questions intimately related to their own thesis research. Postdoctoral trainees will be supported for two years. The primary focus of the postdoctoral training is to build a strong research record. Postdoctoral trainees will also be actively mentored to foster skills in oral presentation, grant writing, and teaching, essential to secure and hold an independent academic position. All trainees will actively participate in monthy meetings in which the participating laboratories present their research. A lineup of faculty and invited speakers will participate in annual seminars and journal clubs that will expose trainees to new developments, historical aspects, ethical issues, and translational aspects of neuroendocrine research. Hands-on workshops will expose the trainees and faculty to cutting-edge technology. Finally an annual symposium will introduce trainees to neuroendocrinologists from across the U.S.A. Training in Neuroendocrinology is relevant to human health as hormone dysfunction is linked to a host of neurological and behavioral disorders, e.g., postpartum depression, sleep and eating disorders, and progress of degenerative diseases such as Alzheimer. Neuroendocrinology can also explain how common environmental pollutants disrupt hormone-brain interactions, thereby causing, e.g., fertility problems, mental retardation, and cancer. Several of the preceptors have research programs directly related to these issues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH020051-10
Application #
7922702
Study Section
Special Emphasis Panel (ZMH1-ERB-L (01))
Program Officer
Desmond, Nancy L
Project Start
2006-08-02
Project End
2011-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
10
Fiscal Year
2010
Total Cost
$128,202
Indirect Cost
Name
University of Massachusetts Amherst
Department
Type
Organized Research Units
DUNS #
153926712
City
Amherst
State
MA
Country
United States
Zip Code
01003
Breves, Jason P; McCormick, Stephen D; Karlstrom, Rolf O (2014) Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia. Gen Comp Endocrinol 203:21-8
Blaustein, Jeffrey D; Ismail, Nafissa (2013) Enduring influence of pubertal stressors on behavioral response to hormones in female mice. Horm Behav 64:390-8
Breves, Jason P; Serizier, Sandy B; Goffin, Vincent et al. (2013) Prolactin regulates transcription of the ion uptake Na+/Cl- cotransporter (ncc) gene in zebrafish gill. Mol Cell Endocrinol 369:98-106
Mahoney, Carrie E; Brewer, Judy McKinley; Bittman, Eric L (2013) Central control of circadian phase in arousal-promoting neurons. PLoS One 8:e67173
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Intlekofer, K A; Petersen, S L (2011) 17?-estradiol and progesterone regulate multiple progestin signaling molecules in the anteroventral periventricular nucleus, ventromedial nucleus and sexually dimorphic nucleus of the preoptic area in female rats. Neuroscience 176:86-92
Bergeron, Sadie A; Tyurina, Oksana V; Miller, Emily et al. (2011) Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development 138:75-85
Intlekofer, K A; Petersen, S L (2011) Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain. Neuroscience 172:55-65
Rood, Benjamin D; De Vries, Geert J (2011) Vasopressin innervation of the mouse (Mus musculus) brain and spinal cord. J Comp Neurol 519:2434-74
Olesen, Kristin M; Ismail, Nafissa; Merchasin, Emily D et al. (2011) Long-term alteration of anxiolytic effects of ovarian hormones in female mice by a peripubertal immune challenge. Horm Behav 60:318-26

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