Developmental neuroscience and psychopathology is a rapidly growing domain with established success and great potential to inform the understanding of the causal pathways and mechanisms of mental illness. This T32, which is focused on this domain, is co-led by Drs. Luby and Barch (with complimentary expertise in developmental psychopathology and neuroscience), and has been very successful in the first cycle of funding, enjoying a highly competitive national applicant pool and successfully launching all of the young scientists who have completed the program thus far. We seek to renew and expand this training grant, adding new expertise in a wider range of neuroimaging measures, as well as new faculty mentors with expertise in the neural effects of the gut microbiome. From a public health perspective, an infusion of new research scientists in the area of developmental neuroscience and psychopathology is a high priority. The proposed multi-disciplinary training approach is guided by a conceptual model that examines emotional, cognitive, behavioral, neurobiological and genetic and environmental aspects of psychopathology from a developmental perspective. Further, this training program is guided by a perspective that recognizes that the risk, onset, and course of psychiatric disorders arises through a complex interplay of brain developmental processes influenced by psychosocial, genetic, and biological (including gut microbial) factors that interact beginning in utero and continue throughout development. Numerous investigators at Washington University in St. Louis (WUSTL) have a rich track record of experience in many aspects of child neuroimaging and related methods, including a focus on structural and functional magnetic resonance approaches in very early childhood, evoked response potentials (ERP) and high density diffuse optical tomography (HD-DOT). Further, WUSTL has an international reputation in psychiatric genetics and gut microbiome work, with many investigators who can bring both behavioral and molecular genetic approaches to bear on understanding the neurobiology of developmental psychopathology. The program mentors have a rich body of available databases derived from longitudinal studies, several of which began in early childhood and in utero. The program mentors provide a unique multidisciplinary training environment in which to pursue this exciting domain focused on childhood, given the established collaborations between child researchers in the WUSTL School of Medicine clinical and basic departments, and the state of the program in neuroscience and neuroimaging at WUSTL that has been at the forefront of developmental cognitive and affective neuroscience. Further, interactions between researchers in basic and clinical developmental neuroscience offer an ongoing opportunity to help train the next generation of young scientists who can pursue questions about the developmental etiology of psychopathology from the perspective of core psychological and neural mechanisms of human behavior that can inform and span traditional boundaries of psychopathology, an approach central to the NIMH Research Domain Criteria Initiative (RDOC).

Public Health Relevance

The area of developmental neuroscience and psychopathology has already demonstrated great potential to inform the understanding of the causal pathways and mechanisms of mental illness, and this training grant renewal seeks to continue to train new research scientists in this area, building on the track record of success over the last 5 years. The division of Child Psychiatry at Washington University School of Medicine is well poised to continue and expand this unique post-doctoral training program based on established expertise in a range of child neuroimaging modalities, genetics, and gut microbiome offered by the multidisciplinary mentoring group. The program is directed by two researchers with complimentary expertise in developmental psychopathology (Dr. Joan Luby) and clinical neuroscience and neuroimaging (Dr. Deanna Barch) who have successfully collaborated on the first cycle of funding, launching several young scientists in this domain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH100019-07
Application #
9664676
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Bechtholt, Anita J
Project Start
2013-07-01
Project End
2023-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Marek, Scott; Dosenbach, Nico U F (2018) The frontoparietal network: function, electrophysiology, and importance of individual precision mapping. Dialogues Clin Neurosci 20:133-140
Luby, Joan L; Agrawal, Arpana; Belden, Andy et al. (2018) Developmental Trajectories of the Orbitofrontal Cortex and Anhedonia in Middle Childhood and Risk for Substance Use in Adolescence in a Longitudinal Sample of Depressed and Healthy Preschoolers. Am J Psychiatry 175:1010-1021
Wheelock, M D; Austin, N C; Bora, S et al. (2018) Altered functional network connectivity relates to motor development in children born very preterm. Neuroimage 183:574-583
Dixon-Gordon, Katherine L; Conkey, Lindsey C; Whalen, Diana J (2018) Recent advances in understanding physical health problems in personality disorders. Curr Opin Psychol 21:1-5
Barch, Deanna M; Belden, Andy C; Tillman, Rebecca et al. (2018) Early Childhood Adverse Experiences, Inferior Frontal Gyrus Connectivity, and the Trajectory of Externalizing Psychopathology. J Am Acad Child Adolesc Psychiatry 57:183-190
Sylvester, Chad M; Smyser, Christopher D; Smyser, Tara et al. (2018) Cortical Functional Connectivity Evident After Birth and Behavioral Inhibition at Age 2. Am J Psychiatry 175:180-187
Sylvester, Chad M; Whalen, Diana J; Belden, Andy C et al. (2018) Shyness and Trajectories of Functional Network Connectivity Over Early Adolescence. Child Dev 89:734-745
Luby, Joan L; Barch, Deanna M; Whalen, Diana et al. (2018) A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression. Am J Psychiatry :appiajp201818030321
Gruber, June; Van Meter, Anna; Gilbert, Kirsten E et al. (2017) Positive Emotion Specificity and Mood Symptoms in an Adolescent Outpatient Sample. Cognit Ther Res 41:393-405
Rogers, Cynthia E; Sylvester, Chad M; Mintz, Carrie et al. (2017) Neonatal Amygdala Functional Connectivity at Rest in Healthy and Preterm Infants and Early Internalizing Symptoms. J Am Acad Child Adolesc Psychiatry 56:157-166

Showing the most recent 10 out of 58 publications