Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007329-03
Application #
3544193
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Project Start
1989-07-10
Project End
1994-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ibuki, T; Dunbar, S A; Yaksh, T L (1997) Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusion. Pain 70:125-32
Dunbar, S A; Yaksh, T L (1997) Spinal infusion of N-methyl-D-aspartate antagonist MK801 induces hypersensitivity to the spinal alpha-2 agonist ST91 in the rat. J Pharmacol Exp Ther 281:1219-25
Calcutt, N A; Chaplan, S R (1997) Spinal pharmacology of tactile allodynia in diabetic rats. Br J Pharmacol 122:1478-82
Dunbar, S; Yaksh, T L (1996) Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Anesthesiology 84:1177-88
Hamra, J G; Yaksh, T L (1996) Halothane inhibits T cell proliferation and interleukin-2 receptor expression in rats. Immunopharmacol Immunotoxicol 18:323-36
Calcutt, N A; Jorge, M C; Yaksh, T L et al. (1996) Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain 68:293-9
Dunbar, S; Yaksh, T L (1996) Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Neurosci Lett 207:33-6
Bach, F W; Chaplan, S R; Jang, J et al. (1995) Cerebrospinal fluid beta-endorphin in models of hyperalgesia in the rat. Regul Pept 59:79-86
Chaplan, S R; Bach, F W; Shafer, S L et al. (1995) Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology 83:775-85
Yaksh, T L; Pogrel, J W; Lee, Y W et al. (1995) Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther 272:207-14

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