The aim of our interdisciplinary Institutional Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD pre-/post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Twenty-seven mentors will participate in this second competitive renewal of this program; 20 are based primarily at CHOP, and 7 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes: 1) a clinical practicum requirement for both MDs and PhDs, 2) formal course work through the U of P Graduate Studies Program, 3) training in responsible conduct of research, 4) training in biostatistics and 5) workshops that cover a variety of important survival skills, including scientific writing, public presentations, grant writing workshops, laboratory management, and career advancement skills. During the first 9 years of our program, we accepted 19 Trainees; 4 were MDs, 14 were PhDs, and 1 was a MD/PhD. 11 of these trainees were female and 4 of these trainees were under-represented minorities. Of the 14 who have completed training, 8 are in faculty positions, 2 are continuing their training at other academic institutions, 1 is a senior research scientist at a pharmaceutical company, 1 is a scientific administrator, and 1 is in private practice. We request continued support for 4 postdoctoral fellows/year and would like to expand our program to include support for 2 pre-doctoral fellows/year. Our goal remains focused on providing a training program unlike any other here at the CHOP or the U of P that is focused on acquired and genetic causes of developmental disability. This program benefits from being in an outstanding environment that commits substantial resources to training, to basic biomedical research, and to a true 'bench to bedside' approach to translational research. Project Relevance: It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. This program strives to fill this need. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
2T32NS007413-11
Application #
7434063
Study Section
Special Emphasis Panel (ZNS1-SRB-P (38))
Program Officer
Korn, Stephen J
Project Start
1998-07-01
Project End
2013-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
11
Fiscal Year
2008
Total Cost
$379,685
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gurda, Brittney L; Bagel, Jessica H; Fisher, Samantha J et al. (2018) LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss. J Neuropathol Exp Neurol 77:229-245
Wellman, Cara L; Bangasser, Debra A; Bollinger, Justin L et al. (2018) Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation. J Neurosci 38:9423-9432
Koberstein, John N; Poplawski, Shane G; Wimmer, Mathieu E et al. (2018) Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism. Sci Signal 11:
Cuoco, Joshua A; Esposito, Anthony W; Moriarty, Shannon et al. (2018) Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background. Cerebellum 17:173-190
Zhao, Ying-Tao; Kwon, Deborah Y; Johnson, Brian S et al. (2018) Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains. Genome Res 28:933-942
Shih, Evelyn K; Robinson, Michael B (2018) Role of Astrocytic Mitochondria in Limiting Ischemic Brain Injury? Physiology (Bethesda) 33:99-112
de Marchena, Ashley; Miller, Judith (2017) ""Frank"" presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder. Autism Res 10:653-662
Grafe, Laura A; Cornfeld, Amanda; Luz, Sandra et al. (2017) Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility. Biol Psychiatry 81:683-692
Schoch, Hannah; Kreibich, Arati S; Ferri, Sarah L et al. (2017) Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene. Biol Psychiatry 81:193-202
Urban, Kimberly R; Gao, Wen-Jun (2017) Psychostimulants As Cognitive Enhancers in Adolescents: More Risk than Reward? Front Public Health 5:260

Showing the most recent 10 out of 123 publications