Primary brain tumors are neurologic diseases that are cancers and cancers that are neurologic diseases. They pose a unique challenge to both neuroscience and cancer research and their study demands a unique training environment, one that recognizes the special nature of the central nervous system and the tumors that develop there. Fellowship opportunities for primary brain tumor research do not currently exist at Mayo Clinic Cancer Center and fellowship opportunities in other laboratories are not relevant as primary training sites for young scientists interested in these tumors. This application requests support to establish a new multidisciplinary research training program to develop scientists who will advance and significantly impact the nation?s Neuro-Oncology research agenda. The Program proposed herein is a basic science, laboratory-based, research training experience under the mentorship of 31 established investigators aligned along four tumor categories and supported by molecular cytogenetics, gene therapy, signaling, invasiveness, epidemiology, and experimental therapeutics along with microarray, imaging and mouse models cores. We initially propose to recruit 1-2 trainees and expand to a steady state of 4 trainees per year. Each trainee will be expected to complete at least two years of hypothesis-driven research supplemented by required attendance at a Core Curriculum that provides the optimal training, education, and career development environment. A unique feature is the development of a """"""""Fusion"""""""" position specifically set aside to mentor a gifted individual from the Mayo Foundation """"""""Predoctoral Program in Neuroscience of Human Disease (T 32 NS 07424)"""""""" through this Training Grant into academic Neuro-Oncology. The Faculty have extensive experience in mentoring pre-and post-doctoral fellows to success, have the necessary core of NIH and other extramural support, and have a productive, stable and cohesive training faculty with an impressive record of joint publications. Qualified candidates from underrepresented populations will be actively recruited to this Program. Application, selection, and trainee progress will be administered through a Training Program Steering Committee.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
1T32NS007494-01A1
Application #
6453405
Study Section
NST-2 Subcommittee (NST)
Program Officer
Finkelstein, Robert
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
1
Fiscal Year
2002
Total Cost
$110,562
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Hardcastle, Jayson; Mills, Lisa; Malo, Courtney S et al. (2017) Immunovirotherapy with measles virus strains in combination with anti-PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment. Neuro Oncol 19:493-502
Kumar, Ravi; de Mooij, Tristan; Peterson, Timothy E et al. (2017) Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane. PLoS One 12:e0179012
Drucker, Kristen L; Gianinni, Caterina; Decker, Paul A et al. (2015) Prognostic significance of multiple kallikreins in high-grade astrocytoma. BMC Cancer 15:565
Drucker, Kristen L; Paulsen, Alex R; Giannini, Caterina et al. (2013) Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma. Neuro Oncol 15:305-18
Chen, Selby; Tanaka, Shota; Giannini, Caterina et al. (2013) Gliomatosis cerebri: clinical characteristics, management, and outcomes. J Neurooncol 112:267-75
Lange, Miranda; Zeng, Yan; Knight, Andrew et al. (2012) Comprehensive Method for Culturing Embryonic Dorsal Root Ganglion Neurons for Seahorse Extracellular Flux XF24 Analysis. Front Neurol 3:175
Toussaint 3rd, L Gerard; Nilson, Allan E; Goble, Jennie M et al. (2012) Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion. Mol Cancer 11:32
Lewis-Tuffin, Laura J; Rodriguez, Fausto; Giannini, Caterina et al. (2010) Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. PLoS One 5:e13665
Rodriguez, Fausto J; Mota, Renan A; Scheithauer, Bernd W et al. (2009) Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma. Brain Pathol 19:623-9
Rodriguez, Fausto J; Scheithauer, Bernd W; Erickson, Lori A et al. (2009) Ectopic low-grade adrenocortical carcinoma in the spinal region: immunohistochemical and molecular cytogenetic study of a pediatric case. Am J Surg Pathol 33:142-8

Showing the most recent 10 out of 13 publications