The purpose of this program is to provide state-of-the-art postdoctoral training in basic research directed at understanding the mechanisms of virus infection and disease in the central nervous system. The program has expanded to include fourteen established and well-funded scientists to act as mentors, with the common interest of understanding the consequences of virus infection of the CMS in a wide variety of viral systems. The continued commitment of the program is to train highly competent and independent researchers that are well-versed in molecular and cell biology and that possess skills and knowledge sufficient to develop productive independent programs in the area of neurovirology. Career development of the trainees is facilitated by a training program that provides 1) full-time research experience under the guidance of experienced senior scientists; 2) instruction in the use of state-of-the-art equipment and technologies; 3) an intellectual environment that provides 4-5 seminars per week by the Institute staff or invited speakers, with opportunities to meet with visiting scientists and faculty members and exchange ideas in neurovirology and related fields; 4) opportunity for formal studies in neurobiology, molecular biology, virology, and immunology; and 5) opportunity for fellows to present their own research findings for critique by other fellows and staff scientists at least once a year. Trainees are from a pool of qualified M.D., Ph.D., and D.V.M. applicants on the basis of 1) previous Academic and investigative performance; 2) evidence of commitment to biomedical research, in particular to virus diseases of the CNS; and 3) recommendations from previous mentors. Appointments will be for a minimum of two years, with three years the norm. Relevance to Public Health: With the continuing HIV/AIDS epidemic and the emergence/re-emergence of other viral pathogens including Hantavirus, West Nile, equine encephalitis virus, measles, poliovirus, and a host of other potential infectious agents, it is clear that there will continue to be a strong need for molecular virologists versed in infections of the CNS. Thus, the overall relevance of this training program is high. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS041219-07
Application #
7252620
Study Section
NST-2 Subcommittee (NST)
Program Officer
Korn, Stephen J
Project Start
2001-07-15
Project End
2011-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
7
Fiscal Year
2007
Total Cost
$201,079
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Walsh, Kevin B; Teijaro, John R; Brock, Linda G et al. (2014) Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. J Virol 88:6281-93
Oldstone, Michael B A; Teijaro, John R; Walsh, Kevin B et al. (2013) Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection. Virology 435:92-101
Sullivan, Brian M; Welch, Megan J; Lemke, Greg et al. (2013) Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? J Virol 87:4071-4
Teijaro, John R; Ng, Cherie; Lee, Andrew M et al. (2013) Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340:207-11
Walsh, Kevin B; Sidney, John; Welch, Megan et al. (2013) CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice. J Virol 87:9949-52
Walsh, Kevin B; Teijaro, John R; Zuniga, Elina I et al. (2012) Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe 11:643-53
Kemball, Christopher C; Flynn, Claudia T; Hosking, Martin P et al. (2012) Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology 429:74-90
Zhang, Adrianna P P; Bornholdt, Zachary A; Liu, Tong et al. (2012) The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog 8:e1002550
Patti, Gary J; Yanes, Oscar; Shriver, Leah P et al. (2012) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat Chem Biol 8:232-4
Teijaro, John R; Walsh, Kevin B; Cahalan, Stuart et al. (2011) Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell 146:980-91

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