? ? Neurodegenerative disorders have a significant health and economic impact upon the nation. In recognition of this fact, the Medical College of Georgia has had a long-term goal of recruiting and fostering the growth of a core of neuroscientists on campus so as to advance our understanding of the biological and molecular basis of these critically important disorders. Through strategic planning and strong institutional support, a nucleus of faculty are now in place on campus, which are equipped with a wide array of techniques and models that can be focused on the study of these complex disorders. An eminent scientist, Robert Yu, leads this cadre of neuroscientists. We have now reached the point of growth where the implementation of a NIH-sponsored training grant would be beneficial, not only to the achievement of our research goals, but also on a global scale, to the continued advancement of science through the training of future neuroscientists. Here, we request support for 3 post- and 1 predoctoral trainees, with an emphasis on the recruitment of minority candidates. Each trainee will be mentored by one of the Program faculty, who have extensive experience in training and are nationally recognized. Training will be monitored and guided by weekly lab meetings, and by a Steering Committee composed of the co-investigators. Outside review of the program goals, achievements and progress by eminent neuroscientists will also occur annually. Since clinical and basic neuroscientists are needed in the field, it is the goal of the training program to produce PhDs and MD/PhDs who are well versed in multiple areas related to the study of neurodegenerative diseases and their repair. With strong institutional support, excellent core resources, and an experienced faculty, the key elements are all in place for a strong training program. Support by the NIH would thus help strengthen a neuroscience program that is uniquely positioned to both advance the field of neurodegenerative research and train its future leaders. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS045543-02
Application #
7089075
Study Section
NST-2 Subcommittee (NST)
Program Officer
Korn, Stephen J
Project Start
2005-07-01
Project End
2010-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$182,153
Indirect Cost
Name
Georgia Health Sciences University
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Witcher, Mark R; Park, Yong D; Lee, Mark R et al. (2010) Three-dimensional relationships between perisynaptic astroglia and human hippocampal synapses. Glia 58:572-87
Fonseca, Jacqueline M; Lambert, Nevin A (2009) Instability of a class a G protein-coupled receptor oligomer interface. Mol Pharmacol 75:1296-9
Yanagisawa, Makoto; Yu, Robert K (2009) N-glycans modulate the activation of gp130 in mouse embryonic neural precursor cells. Biochem Biophys Res Commun 386:101-4
Davidson, Heather Trantham; Xiao, Jiping; Dai, Rujuan et al. (2009) Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus. Eur J Neurosci 29:42-54
Shue, Eveline H; Carson-Walter, Eleanor B; Liu, Yang et al. (2008) Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models. BMC Neurosci 9:29
Trantham-Davidson, Heather; Vazdarjanova, Almira; Dai, Rujuan et al. (2008) Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Behav Brain Res 189:244-9
Bourne, Jennifer N; Kirov, Sergei A; Sorra, Karin E et al. (2007) Warmer preparation of hippocampal slices prevents synapse proliferation that might obscure LTP-related structural plasticity. Neuropharmacology 52:55-9
Witcher, Mark R; Kirov, Sergei A; Harris, Kristen M (2007) Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus. Glia 55:13-23