Movement disorders such as Parkinson?s disease, dystonia, and ataxia strip away the ability to act on our environment. Each disease causes unwanted movements, makes desired movements more difficult to perform, and also affects how we think and process our emotions. To be effective, research into movement disorders must cross disciplines, and enhance the translation of basic science discoveries to help humans move more effectively. This Movement Disorders and Neurorestoration Training (MDNR) program confronts this problem head on by bringing together an outstanding group of mentors with a rich infrastructure and resources to train predoctoral Trainees focused on movement disorders. This program combines a critical mass of well-trained scientists prepared to conduct research focused on the ABC?S of translational research: aetiology, biomarkers/endophenotypes, and causative and symptom based therapies. To do so, the program will encompass three areas with a central theme of movement disorders: a) molecular biology and animal models; b) translational neuroscience and physiology, and c) human motor and cognitive neuroscience. Specific approaches within these themes can range from genetics to molecular to neuroimaging to neurorestoration to behavioral, but the central focus is movement disorders. Trainees are selected from a pool of outstanding students with diverse backgrounds and are admitted by one of five graduate programs. A key feature is that Trainees experience laboratories that cross areas, and dissertation committee members must come from each of the three scientific areas. The MDNR program capitalizes on existing strengths and strategic investments at the University of Florida (UF) including well-established investigators in ataxia, Parkinson?s disease, atypical parkinsonism, and dystonia, outstanding animal research facilities for basic science, world class animal and human imaging facilities, three privately endowed and foundation supported Centers of Excellence for Parkinson?s disease, dystonia, and ataxia, and the UF Center for Movement Disorders and Neurorestoration. This patient-centered clinical research facility maintains the largest, comprehensive clinical research database in the world. Upon entering the program, each trainee prepares an individualized career development plan that consists of a structured didactic program, specialized courses, seminars, and laboratory research. The mentor to mentor interaction that crosses levels of analysis sets up a unique learning environment that will prepare Trainees for a strong future as biomedical scientists that can make a difference in movement disorders. This training program in Movement Disorders and Neurorestoration provides an interdisciplinary training environment that is fundamental to the advancement of research in the etiology and treatment of movement disorders.

Public Health Relevance

Parkinson?s disease and other movement disorders are devastating disorders that disrupt quality of life for individuals and their families. This predoctoral program involving Interdisciplinary Training in Movement Disorders and Neurorestoration (MDNR) is designed to help build a group of rigorously trained, scientifically competent and innovative young scientists who can make a difference in the lives of individuals with movement disorders by advancing research in etiology and treatment of movement disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
3T32NS082168-05S1
Application #
9866676
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2015-05-01
Project End
2021-04-30
Budget Start
2019-05-01
Budget End
2021-04-30
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Florida
Department
Other Health Professions
Type
Schools of Public Health
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Pace, Michael C; Xu, Guilian; Fromholt, Susan et al. (2018) Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease. Acta Neuropathol 136:919-938
Crowley, Samuel; Huang, Haiqing; Tanner, Jared et al. (2018) Considering total intracranial volume and other nuisance variables in brain voxel based morphometry in idiopathic PD. Brain Imaging Behav 12:1-12
Lopez, Francesca V; Ferencz, Beata; Rohl, Brittany Y et al. (2018) Everyday functioning in Parkinson's disease: Evidence from the Revised-Observed Tasks of Daily Living (OTDL-R). Parkinsonism Relat Disord :
Archer, Derek B; Coombes, Stephen A; Chu, Winston T et al. (2018) A widespread visually-sensitive functional network relates to symptoms in essential tremor. Brain 141:472-485
Chung, Jae Woo; Burciu, Roxana G; Ofori, Edward et al. (2018) Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia. Neuroimage Clin 19:559-571
Ayhan, Fatma; Perez, Barbara A; Shorrock, Hannah K et al. (2018) SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. EMBO J 37:
Rutherford, Nicola J; Brooks, Mieu; Riffe, Cara J et al. (2017) Prion-like transmission of ?-synuclein pathology in the context of an NFL null background. Neurosci Lett 661:114-120
Rutherford, Nicola J; Dhillon, Jess-Karan S; Riffe, Cara J et al. (2017) Comparison of the in vivo induction and transmission of ?-synuclein pathology by mutant ?-synuclein fibril seeds in transgenic mice. Hum Mol Genet 26:4906-4915
Chung, Jae W; Ofori, Edward; Misra, Gaurav et al. (2017) Beta-band activity and connectivity in sensorimotor and parietal cortex are important for accurate motor performance. Neuroimage 144:164-173
Dhillon, Jess-Karan S; Riffe, Cara; Moore, Brenda D et al. (2017) A novel panel of ?-synuclein antibodies reveal distinctive staining profiles in synucleinopathies. PLoS One 12:e0184731

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