This is a competing renewal of a five-year Institutional NRSA application for the support of predoctoral students in the interdepartmental Graduate Program in Neuroscience at Emory University. A fundamental strength of this program is the broad interdisciplinary training provided in a wide spectrum of neurobiological issues spanning several basic and clinical neuroscience-related disciplines. Because of the significant growth in highly qualified applicants to this program during the past funding period and the high success rate of current trainees in building up an outstanding record of peer-reviewed publications and successfully competing for external funds at the national level (among the top programs for NRSAs at the national level), we seek support for 10 students per year in this renewal (i.e. 3 more than the current funding state). A total of 94 PhD students (+ 14 new recruits for fall 2015) are enrolled in this program, which has consistently attracted a large and very high quality applicant pool from all over US and a significant number of international applicants with outstanding academic credentials. The program has been extremely successful in enrolling outstanding underrepresented minority (URM) students during the past 5 years, and in attracting a larger pool of high qualified URM to apply. Fifteen percent of the current pool of students in the program are from URM ethnic groups. An Executive Committee representing the 131 (96 on this grant) faculty from 23 departments and the Yerkes National Primate Research Center administers the program. This committee is headed by the Director, who oversees all aspects of program operation, two Directors of Graduate Studies, who monitor student progress, and the Director of Admissions, who is in charge of recruitment of new students in the program. Students in the program receive a broad curriculum of molecular, cellular and systems neuroscience courses in their first two years. A required hypothesis design and grant writing course helps students prepare their thesis proposal (with oral defense) in the form of an NRSA predoctoral fellowship application. They are also required to participate in 3 laboratory rotations before they pick their advisor (usually at the beginning of year 2). A wide variety of elective courses ranging from Basic Mechanisms of Neurological Diseases, Brain imaging and Computational Neuroscience are available to advanced trainees. Finally, students actively participate in various seminar series and receive significant training in teaching, neuroethics and scholar integrity.

Public Health Relevance

This proposal is a competing renewal to support the training of ten pre-doctoral students enrolled in the PhD graduate neuroscience program at Emory University during years 1 or 2 of training. The interdisciplinary Emory neuroscience program comprises a total of 96 training faculty and 94 PhD students involved in neuroscience research that cuts across a wide array of disciplines that range from the understanding of basic neural communication to the treatment of complex neurological and psychiatric disorders. The pool of applicants (including underrepresented minority groups) has constantly raised during the past funding period, while remaining of outstanding quality. Therefore the present application requests the number of slots supported by this training grant to be raised from7 to 10 for the next funding period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS096050-23
Application #
9503800
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Weigand, Letitia Alexis
Project Start
1996-07-01
Project End
2021-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
23
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Emory University
Department
Neurology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Gigante, Eduardo D; Long, Alyssa Bushey; Ben-Ami, Johanna et al. (2018) Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response. Dev Biol 437:152-162
Purcell, Ryan H; Toro, Camilo; Gahl, William A et al. (2017) A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Hum Mutat 38:1751-1760
Perez Diaz, Maylen; Andersen, Monica L; Rice, Kenner C et al. (2017) Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys. Neuropsychopharmacology 42:1531-1538
Ritter-Makinson, Stefanie L; Paquet, Maryse; Bogenpohl, James W et al. (2017) Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience 353:58-75
Pitts, Elizabeth G; Minerva, Adelaide R; Chandler, Erika B et al. (2017) 3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner. Neuropsychopharmacology 42:1962-1971
Ahlgrim, Nathan S; Raper, Jessica; Johnson, Emily et al. (2017) Neonatal perirhinal cortex lesions impair monkeys' ability to modulate their emotional responses. Behav Neurosci 131:359-71
Wingo, A P; Almli, L M; Stevens, J S et al. (2017) Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs. Mol Psychiatry 22:774-783
Maltbie, Eric A; Kaundinya, Gopinath S; Howell, Leonard L (2017) Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action. Behav Pharmacol 28:610-622
Berro, LaĆ­s F; Perez Diaz, Maylen; Maltbie, Eric et al. (2017) Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys. Psychopharmacology (Berl) 234:2607-2617
Thomas, Kristen Therese; Anderson, Bart Russell; Shah, Niraj et al. (2017) Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1? Neurodevelopmental Signal Transduction. Cell Rep 20:1-12

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